FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966893104> ?p ?o ?g. }

• W1966893104 endingPage "204" @default.
• W1966893104 startingPage "197" @default.
• W1966893104 abstract "Increased levels of inflammatory cytokines may play a role in depression. Depressive symptoms can be induced in humans with administration of low-dose lipopolysaccharide (LPS; endotoxin), which activates the innate immune system and causes release of inflammatory cytokines. We previously found that pre-treatment with the serotonin reuptake inhibitor citalopram reduced LPS-induced fatigue and anhedonia. This is a follow-up study to determine whether LPS-induced symptoms could be reduced by pre-treatment with bupropion, a norepinephrine and dopamine reuptake inhibitor. In this double-blind, randomized, placebo-controlled, cross-over study, 10 healthy subjects received intravenous LPS (0.8 ng/kg) after oral pre-treatment with bupropion (75 mg twice a day) or placebo for 7 days. The Montgomery-Åsberg Depression Rating Scale (MADRS), the Profile of Mood States (POMS), and a visual analog scale (VAS) were used to measure depressive symptoms. Serum levels of inflammatory cytokines and chemokines were measured with electrochemiluminescence assays. The results of this study, which must be considered preliminary, showed that LPS administration was associated with (1) increase in serum levels of all cytokines and chemokines assayed; (2) increase in total MADRS score, mostly due to items 7 (lassitude) and 8 (anhedonia); (3) increase in fatigue; (4) decrease in vigor; and (5) decrease in social interest. Bupropion pre-treatment had no statistically significant effect on the innate immune response to LPS or on LPS-induced behavioral changes, suggesting that 1-week pre-treatment with bupropion does not inhibit LPS-induced fatigue and anhedonia, contrary to what was found previously with citalopram." @default.
• W1966893104 created "2016-06-24" @default.
• W1966893104 creator A5010488095 @default.
• W1966893104 creator A5024352309 @default.
• W1966893104 creator A5056238262 @default.
• W1966893104 creator A5059401787 @default.
• W1966893104 date "2013-07-01" @default.
• W1966893104 modified "2023-10-16" @default.
• W1966893104 title "Bupropion pre-treatment of endotoxin-induced depressive symptoms" @default.
• W1966893104 cites W130054925 @default.
• W1966893104 cites W1972187375 @default.
• W1966893104 cites W1973172818 @default.
• W1966893104 cites W1982409595 @default.
• W1966893104 cites W1985438873 @default.
• W1966893104 cites W1986791525 @default.
• W1966893104 cites W1991862424 @default.
• W1966893104 cites W1993197717 @default.
• W1966893104 cites W1996153970 @default.
• W1966893104 cites W1998520631 @default.
• W1966893104 cites W1998878650 @default.
• W1966893104 cites W2002250647 @default.
• W1966893104 cites W2006548108 @default.
• W1966893104 cites W2011291552 @default.
• W1966893104 cites W2012992125 @default.
• W1966893104 cites W2024917272 @default.
• W1966893104 cites W2024920855 @default.
• W1966893104 cites W2026710792 @default.
• W1966893104 cites W2027163418 @default.
• W1966893104 cites W2043189848 @default.
• W1966893104 cites W2043719047 @default.
• W1966893104 cites W2053020615 @default.
• W1966893104 cites W2056648954 @default.
• W1966893104 cites W2062145099 @default.
• W1966893104 cites W2096793039 @default.
• W1966893104 cites W2105065969 @default.
• W1966893104 cites W2108569388 @default.
• W1966893104 cites W2121141076 @default.
• W1966893104 cites W2133918045 @default.
• W1966893104 cites W2135322342 @default.
• W1966893104 cites W2135955660 @default.
• W1966893104 cites W2140505555 @default.
• W1966893104 cites W2143741117 @default.
• W1966893104 cites W2145426948 @default.
• W1966893104 cites W2161296293 @default.
• W1966893104 cites W2164714170 @default.
• W1966893104 cites W2167314970 @default.
• W1966893104 cites W2338816059 @default.
• W1966893104 cites W2751944004 @default.
• W1966893104 doi "https://doi.org/10.1016/j.bbi.2012.10.008" @default.
• W1966893104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23064079" @default.
• W1966893104 hasPublicationYear "2013" @default.
• W1966893104 type Work @default.
• W1966893104 sameAs 1966893104 @default.
• W1966893104 citedByCount "36" @default.
• W1966893104 countsByYear W19668931042013 @default.
• W1966893104 countsByYear W19668931042014 @default.
• W1966893104 countsByYear W19668931042015 @default.
• W1966893104 countsByYear W19668931042016 @default.
• W1966893104 countsByYear W19668931042017 @default.
• W1966893104 countsByYear W19668931042018 @default.
• W1966893104 countsByYear W19668931042019 @default.
• W1966893104 countsByYear W19668931042020 @default.
• W1966893104 countsByYear W19668931042021 @default.
• W1966893104 countsByYear W19668931042022 @default.
• W1966893104 countsByYear W19668931042023 @default.
• W1966893104 crossrefType "journal-article" @default.
• W1966893104 hasAuthorship W1966893104A5010488095 @default.
• W1966893104 hasAuthorship W1966893104A5024352309 @default.
• W1966893104 hasAuthorship W1966893104A5056238262 @default.
• W1966893104 hasAuthorship W1966893104A5059401787 @default.
• W1966893104 hasConcept C126322002 @default.
• W1966893104 hasConcept C142724271 @default.
• W1966893104 hasConcept C170493617 @default.
• W1966893104 hasConcept C204787440 @default.
• W1966893104 hasConcept C27081682 @default.
• W1966893104 hasConcept C2775864247 @default.
• W1966893104 hasConcept C2777843972 @default.
• W1966893104 hasConcept C2778941446 @default.
• W1966893104 hasConcept C2779908668 @default.
• W1966893104 hasConcept C2780092697 @default.
• W1966893104 hasConcept C31487548 @default.
• W1966893104 hasConcept C513476851 @default.
• W1966893104 hasConcept C71924100 @default.
• W1966893104 hasConcept C98274493 @default.
• W1966893104 hasConceptScore W1966893104C126322002 @default.
• W1966893104 hasConceptScore W1966893104C142724271 @default.
• W1966893104 hasConceptScore W1966893104C170493617 @default.
• W1966893104 hasConceptScore W1966893104C204787440 @default.
• W1966893104 hasConceptScore W1966893104C27081682 @default.
• W1966893104 hasConceptScore W1966893104C2775864247 @default.
• W1966893104 hasConceptScore W1966893104C2777843972 @default.
• W1966893104 hasConceptScore W1966893104C2778941446 @default.
• W1966893104 hasConceptScore W1966893104C2779908668 @default.
• W1966893104 hasConceptScore W1966893104C2780092697 @default.
• W1966893104 hasConceptScore W1966893104C31487548 @default.
• W1966893104 hasConceptScore W1966893104C513476851 @default.
• W1966893104 hasConceptScore W1966893104C71924100 @default.
• W1966893104 hasConceptScore W1966893104C98274493 @default.

• next