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• W1966896726 abstract "Cycloprodigiosin hydrochloride (cPrG • HCl), a novel H+/Cl– symporter, induces acidification of the cytosol and leads to apoptosis in rat and human liver cancer cells. In the present study, the effect of cPrG • HCl on a promyelocytic leukemia cell line (HL-60) was examined. cPrG • HCl lowered intracellular pH and induced apoptosis through up-regulation of Fas ligand, activation of stress-activated protein kinase (SAPK/JNK) and caspase. Apoptosis induced by cPrG • HCl was strongly suppressed when a cell-permeable weak base, imidazole, was present, indicating that cytosol acidification introduced by cPrG • HCl triggered caspase activation, leading to apoptosis. Concomitantly, cell differentiation into monocyte was also induced by cPrG • HCl both morphologically and functionally. However, the cPrG • HCl-induced differentiation was not suppressed by addition of imidazole, indicating that the differentiation process is unrelated to cytosol acidification. Further, the differentiation induced by cPrG • HCl was blocked by tyrosine kinase inhibitors (lavendustin A and HMA) but unaffected by the inhibitors of A-kinase (H-89) or C-kinase (H-7). Taken together, these findings suggest that cPrG • HCl, through apoptosis and differentiation induction, may be useful in leukemia treatment. Int. J. Cancer 88:121–128, 2000. © 2000 Wiley-Liss, Inc." @default.
• W1966896726 created "2016-06-24" @default.
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• W1966896726 date "2000-01-01" @default.
• W1966896726 modified "2023-10-16" @default.
• W1966896726 title "Cycloprodigiosin hydrochloride, H+/CL- symporter, induces apoptosis and differentiation in HL-60 cells" @default.
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• W1966896726 doi "https://doi.org/10.1002/1097-0215(20001001)88:1<121::aid-ijc19>3.0.co;2-c" @default.
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