FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966898558> ?p ?o ?g. }

• W1966898558 endingPage "68" @default.
• W1966898558 startingPage "63" @default.
• W1966898558 abstract "Endothelin-1 (ET-1) has been reported to mediate prostaglandin (PG) F(2)alpha (PGF(2)alpha)-induced luteolysis. Prostaglandins E (PGE; PGE(1)+PGE(2)) are associated with implantation, maternal recognition of pregnancy, and are antiluteolytic and luteotropic in vitro and in vivo. ET-1 increased PGE secretion by bovine luteal tissue in vitro from cows where estrus was not synchronized or when estrus was synchronized with lutalyse and did not affect luteal PGF(2)alpha or progesterone secretion, which does not support the concept that ET-1 is luteolytic or mediates PGF(2)alpha luteolysis. Therefore, the objective of this experiment was to determine whether ET-1 infused every 6h from 2400 h on day 10-1800 h on day 18 of the ovine estrous cycle either into the interstitial tissue of the ovarian vascular pedicle (IP) or intrauterine (IU) adjacent to the luteal-containing ovary was luteolytic in ewes. Treatments were: Vehicle-IP; Vehicle-IU; ET-1-IP; or ET-1-IU. Weights of corpora lutea differed (P< or = 0.05) among treatment groups. Weights of corpora lutea at 1800 h on day 18 were: VEH-IP-247+/-38 mg; VEH-IU-195+/-31 mg; ET-1-IP-626+/-74 mg; and ET-1-IU-542+/-69 mg. Luteal weights on day 18 in ET-1-IP or ET-1-IU-treated ewes did not differ (P> or =0.05), but were heavier (P< or =0.05) than in the Vehicle-IP or Vehicle-IU treatment groups which did not differ (P> or =0.05). Profiles of progesterone in jugular venous plasma of both control groups treated with Vehicle-IP or Vehicle-IU were lower (P< or =0.05) than in ewes treated with ET-1-IP or ET-1-IU, which did not differ (P> or =0.05) between ET-1-IP or ET-1-IU treatment groups. Treatment with ET-1-IP or ET-1-IU increased (P< or =0.05) the PGE:PGF(2)alpha ratio when compared to the Vehicle-IP or Vehicle-IU treatment groups, which did not differ (P> or =0.05) between each other. In summary, ET-1 prevented the decrease in luteal weights and the decline in progesterone, but increased the PGE:PGF(2)alpha ratio when compared to controls. Therefore, it is concluded that ET-1 is not luteolytic in ewes, but instead may be luteotropic or antiluteolytic by altering uterine secretion of the PGE:PGF(2)alpha ratio, since PGE(1) or PGE(2) are luteotropic in vitro and in vivo, PGE(1) or PGE(2) prevent PGF(2)alpha-induced luteolysis in vitro and in vivo, and PGE(1) and PGE(2) increase two-fold in ewe endometrium to prevent luteolysis during early pregnancy." @default.
• W1966898558 created "2016-06-24" @default.
• W1966898558 creator A5000979510 @default.
• W1966898558 creator A5010154397 @default.
• W1966898558 creator A5017433394 @default.
• W1966898558 creator A5025622893 @default.
• W1966898558 creator A5030785493 @default.
• W1966898558 creator A5032587535 @default.
• W1966898558 creator A5061914330 @default.
• W1966898558 creator A5066199976 @default.
• W1966898558 creator A5069921175 @default.
• W1966898558 creator A5074245427 @default.
• W1966898558 creator A5091028270 @default.
• W1966898558 date "2009-12-01" @default.
• W1966898558 modified "2023-09-27" @default.
• W1966898558 title "Is endothelin-1 luteolytic or antiluteolytic in ewes?" @default.
• W1966898558 cites W1570401841 @default.
• W1966898558 cites W169066613 @default.
• W1966898558 cites W1800849354 @default.
• W1966898558 cites W1858680866 @default.
• W1966898558 cites W1965209012 @default.
• W1966898558 cites W1970110486 @default.
• W1966898558 cites W1970400072 @default.
• W1966898558 cites W1974593874 @default.
• W1966898558 cites W1974675147 @default.
• W1966898558 cites W1976011053 @default.
• W1966898558 cites W1978150066 @default.
• W1966898558 cites W1980853146 @default.
• W1966898558 cites W1981331401 @default.
• W1966898558 cites W1983508074 @default.
• W1966898558 cites W1984285345 @default.
• W1966898558 cites W1984747547 @default.
• W1966898558 cites W1986219169 @default.
• W1966898558 cites W1989596343 @default.
• W1966898558 cites W1992897439 @default.
• W1966898558 cites W1995059839 @default.
• W1966898558 cites W1995432200 @default.
• W1966898558 cites W1996543040 @default.
• W1966898558 cites W1997666202 @default.
• W1966898558 cites W2001452363 @default.
• W1966898558 cites W2004929492 @default.
• W1966898558 cites W2006529063 @default.
• W1966898558 cites W2007831444 @default.
• W1966898558 cites W2008051850 @default.
• W1966898558 cites W2013240595 @default.
• W1966898558 cites W2016047670 @default.
• W1966898558 cites W2017383739 @default.
• W1966898558 cites W2031432649 @default.
• W1966898558 cites W2034628848 @default.
• W1966898558 cites W2037333916 @default.
• W1966898558 cites W2038724779 @default.
• W1966898558 cites W2041276572 @default.
• W1966898558 cites W2042146282 @default.
• W1966898558 cites W2042265036 @default.
• W1966898558 cites W2045220791 @default.
• W1966898558 cites W2045314690 @default.
• W1966898558 cites W2046979071 @default.
• W1966898558 cites W2052456299 @default.
• W1966898558 cites W2053865302 @default.
• W1966898558 cites W2053893575 @default.
• W1966898558 cites W2055753544 @default.
• W1966898558 cites W2056451621 @default.
• W1966898558 cites W2059537354 @default.
• W1966898558 cites W2060127581 @default.
• W1966898558 cites W2060990042 @default.
• W1966898558 cites W2062240808 @default.
• W1966898558 cites W2062796996 @default.
• W1966898558 cites W2063878171 @default.
• W1966898558 cites W2066050379 @default.
• W1966898558 cites W2067528216 @default.
• W1966898558 cites W2069027033 @default.
• W1966898558 cites W2069915269 @default.
• W1966898558 cites W2074307405 @default.
• W1966898558 cites W2075598759 @default.
• W1966898558 cites W2078101880 @default.
• W1966898558 cites W2080474281 @default.
• W1966898558 cites W2083811489 @default.
• W1966898558 cites W2084459045 @default.
• W1966898558 cites W2088963859 @default.
• W1966898558 cites W2089874445 @default.
• W1966898558 cites W2092859027 @default.
• W1966898558 cites W2094280844 @default.
• W1966898558 cites W2096846307 @default.
• W1966898558 cites W2107692102 @default.
• W1966898558 cites W2110914038 @default.
• W1966898558 cites W2117234772 @default.
• W1966898558 cites W2125138379 @default.
• W1966898558 cites W2125155101 @default.
• W1966898558 cites W2127356121 @default.
• W1966898558 cites W2128779583 @default.
• W1966898558 cites W2139169931 @default.
• W1966898558 cites W2149517932 @default.
• W1966898558 cites W2152242805 @default.
• W1966898558 cites W2154308398 @default.
• W1966898558 cites W2168246783 @default.
• W1966898558 cites W2168423447 @default.
• W1966898558 cites W2169659526 @default.
• W1966898558 cites W2179449110 @default.

• next