FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966899428> ?p ?o ?g. }

• W1966899428 endingPage "47" @default.
• W1966899428 startingPage "38" @default.
• W1966899428 abstract "Although Imatinib has transformed the treatment of chronic myeloid leukemia (CML), it is not curative due to the persistence of resistant cells that can regenerate the disease. We have examined how Bcr-Abl-expressing cells respond to two mechanistically different therapeutic agents, etoposide and Imatinib. We also examined Bcr-Abl expression at low and high levels as elevated expression has been associated with treatment failure. Cells expressing low levels of Bcr-Abl undergo apoptosis in response to the DNA-targeting agent (etoposide), whereas high-Bcr-Abl-expressing cells primarily induce autophagy. Autophagic populations engage a delayed nonapoptotic death; however, sufficient cells evade this and repopulate following the withdrawal of the drug. Non-Bcr-Abl-expressing 32D or Ba/F3 cells induce both apoptosis and autophagy in response to etoposide and can recover. Imatinib treatment induces both apoptosis and autophagy in all Bcr-Abl-expressing cells and populations rapidly recover. Inhibition of autophagy with ATG7 and Beclin1 siRNA significantly reduced the recovery of Imatinib-treated K562 cells, indicating the importance of autophagy for the recovery of treated cells. Combination regimes incorporating agents that disrupt Imatinib-induced autophagy would remain primarily targeted and may improve response to the treatment in CML. Am. J. Hematol., 2011. © 2010 Wiley-Liss, Inc." @default.
• W1966899428 created "2016-06-24" @default.
• W1966899428 creator A5019100879 @default.
• W1966899428 creator A5028806934 @default.
• W1966899428 creator A5047247373 @default.
• W1966899428 creator A5065275381 @default.
• W1966899428 date "2010-12-03" @default.
• W1966899428 modified "2023-10-06" @default.
• W1966899428 title "Autophagy induction by Bcr-Abl-expressing cells facilitates their recovery from a targeted or nontargeted treatment" @default.
• W1966899428 cites W1560977824 @default.
• W1966899428 cites W1963521777 @default.
• W1966899428 cites W1976361611 @default.
• W1966899428 cites W1978485107 @default.
• W1966899428 cites W1987239635 @default.
• W1966899428 cites W1989051519 @default.
• W1966899428 cites W1995705474 @default.
• W1966899428 cites W1999614615 @default.
• W1966899428 cites W2001591494 @default.
• W1966899428 cites W2004691500 @default.
• W1966899428 cites W2005734249 @default.
• W1966899428 cites W2012150510 @default.
• W1966899428 cites W2012153991 @default.
• W1966899428 cites W2012348415 @default.
• W1966899428 cites W2014316424 @default.
• W1966899428 cites W2024712102 @default.
• W1966899428 cites W2034132952 @default.
• W1966899428 cites W2038405639 @default.
• W1966899428 cites W2043722668 @default.
• W1966899428 cites W2047253022 @default.
• W1966899428 cites W2047390792 @default.
• W1966899428 cites W2051850282 @default.
• W1966899428 cites W2054442870 @default.
• W1966899428 cites W2055784390 @default.
• W1966899428 cites W2056917031 @default.
• W1966899428 cites W2058187662 @default.
• W1966899428 cites W2058576674 @default.
• W1966899428 cites W2070881021 @default.
• W1966899428 cites W2074740152 @default.
• W1966899428 cites W2086344594 @default.
• W1966899428 cites W2086853865 @default.
• W1966899428 cites W2090004346 @default.
• W1966899428 cites W2097066287 @default.
• W1966899428 cites W2101390452 @default.
• W1966899428 cites W2101721772 @default.
• W1966899428 cites W2102601355 @default.
• W1966899428 cites W2102983508 @default.
• W1966899428 cites W2104602638 @default.
• W1966899428 cites W2106255061 @default.
• W1966899428 cites W2121003869 @default.
• W1966899428 cites W2134234801 @default.
• W1966899428 cites W2150043714 @default.
• W1966899428 cites W2154959571 @default.
• W1966899428 cites W2165081183 @default.
• W1966899428 cites W2165142542 @default.
• W1966899428 cites W2166270808 @default.
• W1966899428 cites W2227735896 @default.
• W1966899428 cites W4243517959 @default.
• W1966899428 doi "https://doi.org/10.1002/ajh.21914" @default.
• W1966899428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21132731" @default.
• W1966899428 hasPublicationYear "2010" @default.
• W1966899428 type Work @default.
• W1966899428 sameAs 1966899428 @default.
• W1966899428 citedByCount "45" @default.
• W1966899428 countsByYear W19668994282012 @default.
• W1966899428 countsByYear W19668994282013 @default.
• W1966899428 countsByYear W19668994282014 @default.
• W1966899428 countsByYear W19668994282015 @default.
• W1966899428 countsByYear W19668994282016 @default.
• W1966899428 countsByYear W19668994282017 @default.
• W1966899428 countsByYear W19668994282018 @default.
• W1966899428 countsByYear W19668994282019 @default.
• W1966899428 countsByYear W19668994282020 @default.
• W1966899428 countsByYear W19668994282021 @default.
• W1966899428 countsByYear W19668994282022 @default.
• W1966899428 crossrefType "journal-article" @default.
• W1966899428 hasAuthorship W1966899428A5019100879 @default.
• W1966899428 hasAuthorship W1966899428A5028806934 @default.
• W1966899428 hasAuthorship W1966899428A5047247373 @default.
• W1966899428 hasAuthorship W1966899428A5065275381 @default.
• W1966899428 hasConcept C171122931 @default.
• W1966899428 hasConcept C190283241 @default.
• W1966899428 hasConcept C203522944 @default.
• W1966899428 hasConcept C2776694085 @default.
• W1966899428 hasConcept C2777583451 @default.
• W1966899428 hasConcept C2778119113 @default.
• W1966899428 hasConcept C2778729363 @default.
• W1966899428 hasConcept C31573885 @default.
• W1966899428 hasConcept C502942594 @default.
• W1966899428 hasConcept C54355233 @default.
• W1966899428 hasConcept C86803240 @default.
• W1966899428 hasConcept C95444343 @default.
• W1966899428 hasConceptScore W1966899428C171122931 @default.
• W1966899428 hasConceptScore W1966899428C190283241 @default.
• W1966899428 hasConceptScore W1966899428C203522944 @default.
• W1966899428 hasConceptScore W1966899428C2776694085 @default.
• W1966899428 hasConceptScore W1966899428C2777583451 @default.
• W1966899428 hasConceptScore W1966899428C2778119113 @default.
• W1966899428 hasConceptScore W1966899428C2778729363 @default.

• next