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• W1966907522 abstract "Andrographolide, the major diterpenoid lactone from Andrographis paniculata, is toxic against cancer cells. In the present study, we investigated the structure–activity relationships (SARs) of 19 andrographolide analogues which were synthesized by modification at the three hydroxyl groups. A number of the andrographolide analogues showed much higher cytotoxic activities than that of the parent compound on cancer cells including P-388, KB, COL-2, MCF-7, LU-1 and ASK cells. SAR studies of the synthetic analogues indicated that the introduction of silyl ether or triphenylmethyl ether group into C-19 of the parent compound led to increase in toxicity against the cancer cells. The 19-O-triphenylmethyl ether analogue 18 showed higher cytotoxic activity than the potent anticancer drug ellipticine, and this analogue may serve as a potential structure lead for the development of new anticancer drugs." @default.
• W1966907522 created "2016-06-24" @default.
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• W1966907522 date "2012-01-01" @default.
• W1966907522 modified "2023-09-27" @default.
• W1966907522 title "New substituted C-19-andrographolide analogues with potent cytotoxic activities" @default.
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• W1966907522 doi "https://doi.org/10.1016/j.bmcl.2011.11.085" @default.
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