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- W1966913788 abstract "The discovery of small non-coding microRNAs has revealed novel mechanisms of post-translational regulation of gene expression, the implications of which are still incompletely understood. We focused on microRNA 21 (miR-21), which is expressed in cardiac valve endothelium during development, in order to better understand its mechanistic role in cardiac valve development. Using a combination of in vivo gene knockdown in zebrafish and in vitro assays in human cells, we show that miR-21 is necessary for proper development of the atrioventricular valve (AV). We identify pdcd4b as a relevant in vivo target of miR-21 and show that protection of pdcd4b from miR-21 binding results in failure of AV development. In vitro experiments using human pulmonic valve endothelial cells demonstrate that miR-21 overexpression augments endothelial cell migration. PDCD4 knockdown alone was sufficient to enhance endothelial cell migration. These results demonstrate that miR-21 plays a necessary role in cardiac valvulogenesis, in large part due to an obligatory downregulation of PDCD4." @default.
- W1966913788 created "2016-06-24" @default.
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- W1966913788 date "2013-05-15" @default.
- W1966913788 modified "2023-10-06" @default.
- W1966913788 title "miR-21 represses Pdcd4 during cardiac valvulogenesis" @default.
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- W1966913788 doi "https://doi.org/10.1242/dev.084475" @default.
- W1966913788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3640220" @default.
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