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- W1966920041 abstract "Following a single injection of MNU into intact mice, a high incidence of leukaemia (90%) is obtained, with a 50% induction time of 200 days. Immunological studies indicate that the θ antigen is expressed on the leukaemic cells. Thymectomized MNU treated mice had a 50% induction time of 500 days, and the incidence was somewhat lower. Leukaemias failed to develop in MNU treated T lymphocyte deficient animals and in lethally irradiated, or thymectomized lethally irradiated mice reconstituted with MNU treated bone marrow. It is suggested that the T lymphocytes rather than the haemopoietic stem cells or pre-T cells are the target cells in MNU leukaemogenesis." @default.
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- W1966920041 date "1974-10-01" @default.
- W1966920041 modified "2023-10-08" @default.
- W1966920041 title "Studies on the Mechanisms of Chemical Leukaemogenesis" @default.
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- W1966920041 doi "https://doi.org/10.1038/bjc.1974.200" @default.
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