FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966920849> ?p ?o ?g. }

• W1966920849 endingPage "24" @default.
• W1966920849 startingPage "16" @default.
• W1966920849 abstract "Certain cells of the periodontium are necessary for the regeneration of tissues that are destroyed as a result of periodontal disease. There has been debate regarding which cells are the primary participants in periodontal regeneration. It is a well-known fact that osteoblasts are essential in new bone formation, but controversy surrounds the role that gingival fibroblasts may play in the regeneration of the hard tissues of the periodontium. If gingival fibroblasts could contribute to the regeneration of these tissues, they might provide an additional source of progenitor cells. The bone morphogenetic proteins are potent stimulators of cell differentiation and have been shown to induce new bone formation in many experimental models. This project investigated the ability of recombinant human bone morphogenetic protein-2 (rhBMP-2) to (1) enhance the production of markers of osteoblastlike cells (osteocalcin and mineralization in culture) in human osteosarcoma cells (MG63) and to (2) induce the expression of an osteoblast phenotype in cultured human gingival fibroblasts (HGFs). MG63 cells and pooled HGFs were exposed to varying concentrations of rhBMP-2 for 24, 48, and 72 hours after 9 days in culture, and osteocalcin levels were measured by enzyme immunosorbent assay in the cell supernatants. In addition, the cells were exposed to rhBMP-2 for 72 hours after 18 days in culture, and mineralization was determined by the Von Kossa stain. The rhBMP-2 had an inhibitory effect on both osteocalcin production and mineralization (p < 0.05) in MG63 cells compared with untreated controls. In addition, increasing doses of rhBMP-2 inhibited both osteocalcin and mineralization in HGF cells. These results suggest that HGFs can express an osteoblastic phenotype when exposed to rhBMP-2; however, rhBMP-2 has inhibitory effects at higher rhBMP-2 doses in both cell types and may, in fact, be inhibitory to MG63 cells." @default.
• W1966920849 created "2016-06-24" @default.
• W1966920849 creator A5017238479 @default.
• W1966920849 creator A5019167207 @default.
• W1966920849 creator A5042230007 @default.
• W1966920849 creator A5056881217 @default.
• W1966920849 creator A5087266935 @default.
• W1966920849 creator A5089724672 @default.
• W1966920849 date "2001-02-01" @default.
• W1966920849 modified "2023-09-27" @default.
• W1966920849 title "The Effects of rhBMP-2 on Human Osteosarcoma Cells and Human Gingival FibroblastsINVITRO" @default.
• W1966920849 cites W1507752960 @default.
• W1966920849 cites W1552563052 @default.
• W1966920849 cites W1922409394 @default.
• W1966920849 cites W1935346479 @default.
• W1966920849 cites W1940573823 @default.
• W1966920849 cites W1968822620 @default.
• W1966920849 cites W1969916098 @default.
• W1966920849 cites W1982212551 @default.
• W1966920849 cites W2002156733 @default.
• W1966920849 cites W2005097199 @default.
• W1966920849 cites W2012333093 @default.
• W1966920849 cites W2012366026 @default.
• W1966920849 cites W2012503485 @default.
• W1966920849 cites W2014958740 @default.
• W1966920849 cites W2016296460 @default.
• W1966920849 cites W2016980922 @default.
• W1966920849 cites W2017051286 @default.
• W1966920849 cites W2018449417 @default.
• W1966920849 cites W2028463483 @default.
• W1966920849 cites W2045545749 @default.
• W1966920849 cites W2056984915 @default.
• W1966920849 cites W2061849937 @default.
• W1966920849 cites W2111098390 @default.
• W1966920849 cites W2132489380 @default.
• W1966920849 cites W2160864868 @default.
• W1966920849 cites W2405640371 @default.
• W1966920849 cites W406552389 @default.
• W1966920849 cites W2410682121 @default.
• W1966920849 doi "https://doi.org/10.1563/1548-1336(2001)027<0016:teoroh>2.3.co;2" @default.
• W1966920849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11326537" @default.
• W1966920849 hasPublicationYear "2001" @default.
• W1966920849 type Work @default.
• W1966920849 sameAs 1966920849 @default.
• W1966920849 citedByCount "7" @default.
• W1966920849 countsByYear W19669208492015 @default.
• W1966920849 countsByYear W19669208492017 @default.
• W1966920849 countsByYear W19669208492019 @default.
• W1966920849 countsByYear W19669208492020 @default.
• W1966920849 crossrefType "journal-article" @default.
• W1966920849 hasAuthorship W1966920849A5017238479 @default.
• W1966920849 hasAuthorship W1966920849A5019167207 @default.
• W1966920849 hasAuthorship W1966920849A5042230007 @default.
• W1966920849 hasAuthorship W1966920849A5056881217 @default.
• W1966920849 hasAuthorship W1966920849A5087266935 @default.
• W1966920849 hasAuthorship W1966920849A5089724672 @default.
• W1966920849 hasBestOaLocation W19669208491 @default.
• W1966920849 hasConcept C104317684 @default.
• W1966920849 hasConcept C131075544 @default.
• W1966920849 hasConcept C160160445 @default.
• W1966920849 hasConcept C16685009 @default.
• W1966920849 hasConcept C171056886 @default.
• W1966920849 hasConcept C181199279 @default.
• W1966920849 hasConcept C185592680 @default.
• W1966920849 hasConcept C199343813 @default.
• W1966920849 hasConcept C201750760 @default.
• W1966920849 hasConcept C202751555 @default.
• W1966920849 hasConcept C2778260815 @default.
• W1966920849 hasConcept C2778380114 @default.
• W1966920849 hasConcept C28328180 @default.
• W1966920849 hasConcept C31507581 @default.
• W1966920849 hasConcept C54355233 @default.
• W1966920849 hasConcept C55493867 @default.
• W1966920849 hasConcept C66694092 @default.
• W1966920849 hasConcept C71924100 @default.
• W1966920849 hasConcept C81885089 @default.
• W1966920849 hasConcept C86803240 @default.
• W1966920849 hasConcept C95444343 @default.
• W1966920849 hasConceptScore W1966920849C104317684 @default.
• W1966920849 hasConceptScore W1966920849C131075544 @default.
• W1966920849 hasConceptScore W1966920849C160160445 @default.
• W1966920849 hasConceptScore W1966920849C16685009 @default.
• W1966920849 hasConceptScore W1966920849C171056886 @default.
• W1966920849 hasConceptScore W1966920849C181199279 @default.
• W1966920849 hasConceptScore W1966920849C185592680 @default.
• W1966920849 hasConceptScore W1966920849C199343813 @default.
• W1966920849 hasConceptScore W1966920849C201750760 @default.
• W1966920849 hasConceptScore W1966920849C202751555 @default.
• W1966920849 hasConceptScore W1966920849C2778260815 @default.
• W1966920849 hasConceptScore W1966920849C2778380114 @default.
• W1966920849 hasConceptScore W1966920849C28328180 @default.
• W1966920849 hasConceptScore W1966920849C31507581 @default.
• W1966920849 hasConceptScore W1966920849C54355233 @default.
• W1966920849 hasConceptScore W1966920849C55493867 @default.
• W1966920849 hasConceptScore W1966920849C66694092 @default.
• W1966920849 hasConceptScore W1966920849C71924100 @default.
• W1966920849 hasConceptScore W1966920849C81885089 @default.
• W1966920849 hasConceptScore W1966920849C86803240 @default.

• next