FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966933087> ?p ?o ?g. }

• W1966933087 endingPage "1062" @default.
• W1966933087 startingPage "1047" @default.
• W1966933087 abstract "The effects of substance P and related tachykinins on intrinsic membrane properties and synaptic responses of neurons in cortical slices were determined. Substance P had no detectable effect on membrane properties of principal neurons in layer II or V of the rat medial entorhinal cortex or on neurons in either layer of the anterior cingulate cortex. Specific agonists at the neurokinin1-receptor were also without effect as were agonists at both neurokinin1- and neurokinin3-receptors. Substance P hyperpolarized a small number of principal neurons. These responses were weak and desensitized with repeated applications. Similar effects were seen with other neurokinin1-receptor agonists. Excitatory synaptic potentials mediated by either alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate- or N-methyl-D-aspartate-receptors in principal neurons of the entorhinal cortex were unaffected by substance P. Responses of entorhinal neurons to iontophoretically applied glutamate and N-methyl-D-aspartate were also unaffected. Inhibitory synaptic potentials mediated by either GABA(A)- or GABA(B)-receptors in entorhinal neurons were slightly but consistently enhanced by substance P. Neurons identified as interneurons on the basis of their firing characteristics were consistently depolarized by substance P. These responses also desensitized with repeated applications. Spontaneous epileptiform discharges evoked in entorhinal cortex by perfusion with a GABA(A)-receptor antagonist (bicuculline), were reduced in frequency and, sometimes, in duration by substance P. This effect was mimicked by other neurokinin1-receptor agonists and blocked by neurokinin1-receptor antagonists. It was also mimicked by neurokinin A but not by a specific neurokinin1-receptor agonist. The reduction in frequency of discharges was also mimicked by a GABA(B)-receptor agonist, L-baclofen, and blocked by the GABA(B)-receptor antagonist, CGP55845A. Neurokinin B, and a specific neurokinin1-receptor agonist (senktide), increased the frequency and (sometimes) duration of epileptiform discharges. Substance P could also increase frequency but this usually succeeded or preceded a decrease in frequency. The effect of neurokinin B was reduced by a metabotropic glutamate receptor antagonist. Substance P appears to have little direct effect on principal neurons of the entorhinal cortex but may hyperpolarize them indirectly by activating interneurons and releasing GABA. This indirect inhibition may be responsible for the ability of substance P to reduce the frequency of epileptiform discharges in the entorhinal cortex and may suggest that neurokinin1-receptor agonists have potential as anticonvulsant drugs." @default.
• W1966933087 created "2016-06-24" @default.
• W1966933087 creator A5011190934 @default.
• W1966933087 creator A5022393028 @default.
• W1966933087 creator A5053692849 @default.
• W1966933087 date "1998-01-01" @default.
• W1966933087 modified "2023-09-28" @default.
• W1966933087 title "Tachykinins may modify spontaneous epileptiform activity in the rat entorhinal cortex in vitro by activating GABAergic inhibition" @default.
• W1966933087 cites W1635864650 @default.
• W1966933087 cites W1963931614 @default.
• W1966933087 cites W1969256591 @default.
• W1966933087 cites W1973137251 @default.
• W1966933087 cites W1974630918 @default.
• W1966933087 cites W1976197643 @default.
• W1966933087 cites W1976286405 @default.
• W1966933087 cites W1977526257 @default.
• W1966933087 cites W1980839404 @default.
• W1966933087 cites W1983354217 @default.
• W1966933087 cites W1987792073 @default.
• W1966933087 cites W1989233068 @default.
• W1966933087 cites W1995314962 @default.
• W1966933087 cites W2000559525 @default.
• W1966933087 cites W2003186917 @default.
• W1966933087 cites W2004099371 @default.
• W1966933087 cites W2008054678 @default.
• W1966933087 cites W2009029549 @default.
• W1966933087 cites W2011800151 @default.
• W1966933087 cites W2014430418 @default.
• W1966933087 cites W2016975485 @default.
• W1966933087 cites W2018792440 @default.
• W1966933087 cites W2021099208 @default.
• W1966933087 cites W2021918777 @default.
• W1966933087 cites W2022146257 @default.
• W1966933087 cites W2027632343 @default.
• W1966933087 cites W2027998184 @default.
• W1966933087 cites W2028014061 @default.
• W1966933087 cites W2038078084 @default.
• W1966933087 cites W2039547266 @default.
• W1966933087 cites W2049233838 @default.
• W1966933087 cites W2062392936 @default.
• W1966933087 cites W2067839789 @default.
• W1966933087 cites W2072774499 @default.
• W1966933087 cites W2075285126 @default.
• W1966933087 cites W2078354420 @default.
• W1966933087 cites W2080869223 @default.
• W1966933087 cites W2090246392 @default.
• W1966933087 cites W2093225726 @default.
• W1966933087 cites W2095334874 @default.
• W1966933087 cites W2114389701 @default.
• W1966933087 cites W2124192107 @default.
• W1966933087 cites W2150122044 @default.
• W1966933087 cites W2159348568 @default.
• W1966933087 cites W2170741779 @default.
• W1966933087 cites W2416575665 @default.
• W1966933087 doi "https://doi.org/10.1016/s0306-4522(97)00469-7" @default.
• W1966933087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9502245" @default.
• W1966933087 hasPublicationYear "1998" @default.
• W1966933087 type Work @default.
• W1966933087 sameAs 1966933087 @default.
• W1966933087 citedByCount "28" @default.
• W1966933087 countsByYear W19669330872012 @default.
• W1966933087 countsByYear W19669330872015 @default.
• W1966933087 countsByYear W19669330872021 @default.
• W1966933087 crossrefType "journal-article" @default.
• W1966933087 hasAuthorship W1966933087A5011190934 @default.
• W1966933087 hasAuthorship W1966933087A5022393028 @default.
• W1966933087 hasAuthorship W1966933087A5053692849 @default.
• W1966933087 hasConcept C112592302 @default.
• W1966933087 hasConcept C118303440 @default.
• W1966933087 hasConcept C126322002 @default.
• W1966933087 hasConcept C134018914 @default.
• W1966933087 hasConcept C168258287 @default.
• W1966933087 hasConcept C169760540 @default.
• W1966933087 hasConcept C170493617 @default.
• W1966933087 hasConcept C17077164 @default.
• W1966933087 hasConcept C185592680 @default.
• W1966933087 hasConcept C2776533618 @default.
• W1966933087 hasConcept C2778938600 @default.
• W1966933087 hasConcept C2779177108 @default.
• W1966933087 hasConcept C2780715579 @default.
• W1966933087 hasConcept C2780763569 @default.
• W1966933087 hasConcept C2781161787 @default.
• W1966933087 hasConcept C55493867 @default.
• W1966933087 hasConcept C61174792 @default.
• W1966933087 hasConcept C71924100 @default.
• W1966933087 hasConcept C86803240 @default.
• W1966933087 hasConceptScore W1966933087C112592302 @default.
• W1966933087 hasConceptScore W1966933087C118303440 @default.
• W1966933087 hasConceptScore W1966933087C126322002 @default.
• W1966933087 hasConceptScore W1966933087C134018914 @default.
• W1966933087 hasConceptScore W1966933087C168258287 @default.
• W1966933087 hasConceptScore W1966933087C169760540 @default.
• W1966933087 hasConceptScore W1966933087C170493617 @default.
• W1966933087 hasConceptScore W1966933087C17077164 @default.
• W1966933087 hasConceptScore W1966933087C185592680 @default.
• W1966933087 hasConceptScore W1966933087C2776533618 @default.
• W1966933087 hasConceptScore W1966933087C2778938600 @default.
• W1966933087 hasConceptScore W1966933087C2779177108 @default.

• next