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- W1966945158 endingPage "S89" @default.
- W1966945158 startingPage "S78" @default.
- W1966945158 abstract "Duchenne muscular dystrophy is an X-linked recessive muscle wasting disease caused by the absence of the muscle cytoskeletal protein, dystrophin. Dystrophin is a member of the spectrin superfamily of proteins and is closely related in sequence similarity and functional motifs to three proteins that constitute the dystrophin related protein family, including the autosomal homologue, utrophin. An alternative strategy circumventing many problems associated with somatic gene therapies for Duchenne muscular dystrophy has arisen from the demonstration that utrophin can functionally substitute for dystrophin and its over-expression in muscles of dystrophin-null transgenic mice completely prevents the phenotype arising from dystrophin deficiency. One potential approach to increase utrophin levels in muscle for possible therapeutic purpose in humans is to increase expression of the utrophin gene at a transcriptional level via promoter activation. This has lead to an interest in the identification and manipulation of important regulatory regions and/or molecules that increase the expression of utrophin and their delivery to dystrophin-deficient tissue. As pre-existing cellular mechanisms are utilized, this approach would avoid many problems associated with conventional gene therapies." @default.
- W1966945158 created "2016-06-24" @default.
- W1966945158 creator A5005383467 @default.
- W1966945158 creator A5088033831 @default.
- W1966945158 date "2002-10-01" @default.
- W1966945158 modified "2023-10-01" @default.
- W1966945158 title "The role of utrophin in the potential therapy of Duchenne muscular dystrophy" @default.
- W1966945158 cites W153444934 @default.
- W1966945158 cites W1581448682 @default.
- W1966945158 cites W1587561974 @default.
- W1966945158 cites W1588816757 @default.
- W1966945158 cites W1590589467 @default.
- W1966945158 cites W176375325 @default.
- W1966945158 cites W1880554115 @default.
- W1966945158 cites W1941310785 @default.
- W1966945158 cites W1964733862 @default.
- W1966945158 cites W1966387132 @default.
- W1966945158 cites W1967261851 @default.
- W1966945158 cites W1967314034 @default.
- W1966945158 cites W1968492247 @default.
- W1966945158 cites W1972568955 @default.
- W1966945158 cites W1972735584 @default.
- W1966945158 cites W1973181458 @default.
- W1966945158 cites W1981106225 @default.
- W1966945158 cites W1983555241 @default.
- W1966945158 cites W1987980762 @default.
- W1966945158 cites W1990585109 @default.
- W1966945158 cites W1990802363 @default.
- W1966945158 cites W1990907625 @default.
- W1966945158 cites W1992733076 @default.
- W1966945158 cites W1994545758 @default.
- W1966945158 cites W1995621893 @default.
- W1966945158 cites W1999008715 @default.
- W1966945158 cites W2001207531 @default.
- W1966945158 cites W2003708679 @default.
- W1966945158 cites W2003922674 @default.
- W1966945158 cites W2009441808 @default.
- W1966945158 cites W2010203981 @default.
- W1966945158 cites W2013028019 @default.
- W1966945158 cites W2013266176 @default.
- W1966945158 cites W2014026136 @default.
- W1966945158 cites W2015114304 @default.
- W1966945158 cites W2018174554 @default.
- W1966945158 cites W2018600945 @default.
- W1966945158 cites W2019563312 @default.
- W1966945158 cites W2021517918 @default.
- W1966945158 cites W2021651525 @default.
- W1966945158 cites W2022885740 @default.
- W1966945158 cites W2023972061 @default.
- W1966945158 cites W2026728314 @default.
- W1966945158 cites W2026923445 @default.
- W1966945158 cites W2037756690 @default.
- W1966945158 cites W2038546974 @default.
- W1966945158 cites W2040106208 @default.
- W1966945158 cites W2043217967 @default.
- W1966945158 cites W2043391835 @default.
- W1966945158 cites W2044046837 @default.
- W1966945158 cites W2045443083 @default.
- W1966945158 cites W2045584725 @default.
- W1966945158 cites W2047478593 @default.
- W1966945158 cites W2048389996 @default.
- W1966945158 cites W2051270549 @default.
- W1966945158 cites W2051890736 @default.
- W1966945158 cites W2053605554 @default.
- W1966945158 cites W2055224057 @default.
- W1966945158 cites W2056102481 @default.
- W1966945158 cites W2059574464 @default.
- W1966945158 cites W2062746471 @default.
- W1966945158 cites W2063118451 @default.
- W1966945158 cites W2063768105 @default.
- W1966945158 cites W2064200753 @default.
- W1966945158 cites W2064217024 @default.
- W1966945158 cites W2073297965 @default.
- W1966945158 cites W2073377967 @default.
- W1966945158 cites W2078680005 @default.
- W1966945158 cites W2080843993 @default.
- W1966945158 cites W2083537465 @default.
- W1966945158 cites W2083630952 @default.
- W1966945158 cites W2084670194 @default.
- W1966945158 cites W2086224626 @default.
- W1966945158 cites W2086327849 @default.
- W1966945158 cites W2087372569 @default.
- W1966945158 cites W2090429649 @default.
- W1966945158 cites W2091212285 @default.
- W1966945158 cites W2095268620 @default.
- W1966945158 cites W2099622916 @default.
- W1966945158 cites W2099914544 @default.
- W1966945158 cites W2101794818 @default.
- W1966945158 cites W2104368344 @default.
- W1966945158 cites W2108922768 @default.
- W1966945158 cites W2110800155 @default.
- W1966945158 cites W2111515815 @default.
- W1966945158 cites W2112090184 @default.
- W1966945158 cites W2114355077 @default.
- W1966945158 cites W2117044960 @default.
- W1966945158 cites W2120924545 @default.
- W1966945158 cites W2128940002 @default.
- W1966945158 cites W2129529502 @default.