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- W1966945392 abstract "Abstract A spontaneously firing giant neurone (the PON, periodically oscillating neurone) was identified in suboesophageal ganglia of Achatina fulica Ferussac . Effects of four stereoisomers of β-hydroxy- glutamic acid (BHGA) and their analogues were examined on the PON excitability. Erythro- l - and threo- l -BHGA showed an inhibitory effect on the PON, while erythro- d - and threo- d -BHGA had no effect. The l -configuration being essential for producing the effect. Critical concentrations of erythro- l - and threo- l -BHGA to produce the effect (by the bath application) were respectively 10 −6 ∼ 3 × 10 −6 kg / l and 3 × 10 −5 ∼ 10 −4 kg / l . l - and d -glutamic acid, allo-γ-hydroxy- l -glutamic acid, erythro- and threo-β-hydroxy- dl -glutamine and erythro- and threo-β-hydroxy- dl -α-glutamine had no effect at 10 −4 kg/1 on the PON. Of the heterocyclic compounds examined, ibotenic acid (IA), quisqualic acid (QA) and three isomers of tricholomic acid (TA) showed an inhibitory effect. The critical concentrations of IA, QA and TA were respectively 3 × 10 −6 ∼ 10 −5 kg /1, 10 −5 kg / l and 10 −4 kg /1. In the chloride-free medium, erythro- l -BHGA, IA and QA (by the microdrop application) showed the same effect as in the physiological state. The PON inhibition caused by these substances was not dependent on chloride ions." @default.
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- W1966945392 date "1977-12-01" @default.
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- W1966945392 title "Structure-activity relationships of β-hydroxyglutamic acid and its relatives on the excitability of an identifiable giant neurone of african giant snail (Achatina fulica ferussac)" @default.
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- W1966945392 doi "https://doi.org/10.1016/0028-3908(77)90147-2" @default.
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