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- W1966946883 endingPage "107" @default.
- W1966946883 startingPage "97" @default.
- W1966946883 abstract "Activation of transcription factor NF-kappaB can affect the expression of several hundred genes, many of which are involved in inflammation and immunity. The proper NF-kappaB transcriptional response is primarily regulated by post-translational modification of NF-kappaB signaling constituents. Herein, we review the accumulating evidence suggesting that alternative splicing of NF-kappaB signaling components is another means of controlling NF-kappaB signaling. Several alternative splicing events in both the tumor necrosis factor and Toll/interleukin-1 NF-kappaB signaling pathways can inhibit the NF-kappaB response, whereas others enhance NF-kappaB signaling. Alternative splicing of mRNAs encoding some NF-kappaB signaling components can be induced by prolonged exposure to an NF-kappaB-activating signal, such as lipopolysaccharide, suggesting a mechanism for negative feedback to dampen excessive NF-kappaB signaling. Moreover, some NF-kappaB alternative splicing events appear to be specific for certain diseases, and could serve as therapeutic targets or biomarkers." @default.
- W1966946883 created "2016-06-24" @default.
- W1966946883 creator A5042073445 @default.
- W1966946883 creator A5071552777 @default.
- W1966946883 date "2008-11-01" @default.
- W1966946883 modified "2023-10-17" @default.
- W1966946883 title "Alternative splicing in the NF-κB signaling pathway" @default.
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