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- W1966958047 abstract "Metallodaunomycin has been shown to cleave DNA only in the presence of oxygen, a reducing agent and a metal ion under reaction conditions similar to those used for the cuprous-phenanthroline complex. The intermediacy of 02-. and H2O2 has been substantiated by experiments with superoxide dismutase and catalase, respectively. Only partial inhibition by OH. scavengers was observed. An important feature of the reaction is that no specificity for Cu(II) was observed. This observation has led us to propose a reaction mechanism different from that proposed for the cuprous-phenanthroline complex. The mechanism proposed includes a catalytic role for metal ions other than Cu(II) as well as the direct participation of products of metal-catalyzed redox reactions such as semiquinone and/or hydroquinone of daunomycin." @default.
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- W1966958047 date "1986-04-01" @default.
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- W1966958047 title "Degradation of DNA by metalloanthracyclines: Requirement for metal ions" @default.
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- W1966958047 doi "https://doi.org/10.1016/0006-291x(86)90868-5" @default.
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