Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966961002> ?p ?o ?g. }
- W1966961002 endingPage "80" @default.
- W1966961002 startingPage "77" @default.
- W1966961002 abstract "Ghrelin (GHR) is an orexigenic gut peptide that interacts with ghrelin receptors (GHR-Rs) to modulate brain reinforcement circuits. Systemic GHR infusions augment cocaine stimulated locomotion and conditioned place preference (CPP) in rats, whereas genetic or pharmacological ablation of GHR-Rs has been shown to attenuate the acute locomotor-enhancing effects of nicotine, cocaine, amphetamine and alcohol and to blunt the CPP induced by food, alcohol, amphetamine and cocaine in mice. The stimulant nicotine can induce CPP and like amphetamine and cocaine, repeated administration of nicotine induces locomotor sensitization in rats. A key issue is whether pharmacological antagonism of GHR-Rs would similarly attenuate nicotine-induced locomotor sensitization. To examine the role of GHR-Rs in the behavioral sensitizing effects of nicotine, adult male rats were injected with either 0, 3 or 6 mg/kg of the GHR-R receptor antagonist JMV 2959 (i.p.) and 20 min later with either vehicle or 0.4 mg/kg nicotine hydrogen tartrate (s.c.) on each of 7 consecutive days. Rats treated with nicotine alone showed robust locomotor sensitization, whereas rats pretreated with JMV 2959 showed significantly attenuated nicotine-induced hyperlocomotion. These results suggest that GHR-R activity is required for the induction of locomotor sensitization to nicotine and complement an emerging literature implicating central GHR systems in drug reward/reinforcement." @default.
- W1966961002 created "2016-06-24" @default.
- W1966961002 creator A5011800585 @default.
- W1966961002 creator A5042894117 @default.
- W1966961002 creator A5052978566 @default.
- W1966961002 creator A5055322102 @default.
- W1966961002 creator A5057996602 @default.
- W1966961002 creator A5064733011 @default.
- W1966961002 creator A5071557196 @default.
- W1966961002 creator A5074370028 @default.
- W1966961002 date "2011-12-01" @default.
- W1966961002 modified "2023-09-30" @default.
- W1966961002 title "Pharmacologic antagonism of ghrelin receptors attenuates development of nicotine induced locomotor sensitization in rats" @default.
- W1966961002 cites W1492363512 @default.
- W1966961002 cites W1544616348 @default.
- W1966961002 cites W1592879775 @default.
- W1966961002 cites W1637971961 @default.
- W1966961002 cites W1871710146 @default.
- W1966961002 cites W1963825419 @default.
- W1966961002 cites W1970697913 @default.
- W1966961002 cites W1973386334 @default.
- W1966961002 cites W1977685499 @default.
- W1966961002 cites W1978384766 @default.
- W1966961002 cites W1985071684 @default.
- W1966961002 cites W1988606404 @default.
- W1966961002 cites W2002561597 @default.
- W1966961002 cites W2005168887 @default.
- W1966961002 cites W2010355342 @default.
- W1966961002 cites W2018695754 @default.
- W1966961002 cites W2027867206 @default.
- W1966961002 cites W2032587202 @default.
- W1966961002 cites W2035600501 @default.
- W1966961002 cites W2038421400 @default.
- W1966961002 cites W2038944901 @default.
- W1966961002 cites W2039578408 @default.
- W1966961002 cites W2040524668 @default.
- W1966961002 cites W2053680491 @default.
- W1966961002 cites W2053820421 @default.
- W1966961002 cites W2054668681 @default.
- W1966961002 cites W2054841494 @default.
- W1966961002 cites W2055991690 @default.
- W1966961002 cites W2061175278 @default.
- W1966961002 cites W2069496939 @default.
- W1966961002 cites W2071217208 @default.
- W1966961002 cites W2071677128 @default.
- W1966961002 cites W2085372550 @default.
- W1966961002 cites W2085946360 @default.
- W1966961002 cites W2086613009 @default.
- W1966961002 cites W2086894078 @default.
- W1966961002 cites W2086950122 @default.
- W1966961002 cites W2087528676 @default.
- W1966961002 cites W2089800528 @default.
- W1966961002 cites W2103992232 @default.
- W1966961002 cites W2115651249 @default.
- W1966961002 cites W2139789471 @default.
- W1966961002 cites W2145729053 @default.
- W1966961002 cites W2154294326 @default.
- W1966961002 cites W2160585483 @default.
- W1966961002 cites W2162198402 @default.
- W1966961002 cites W2163865122 @default.
- W1966961002 doi "https://doi.org/10.1016/j.regpep.2011.08.014" @default.
- W1966961002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3197247" @default.
- W1966961002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21903141" @default.
- W1966961002 hasPublicationYear "2011" @default.
- W1966961002 type Work @default.
- W1966961002 sameAs 1966961002 @default.
- W1966961002 citedByCount "47" @default.
- W1966961002 countsByYear W19669610022012 @default.
- W1966961002 countsByYear W19669610022013 @default.
- W1966961002 countsByYear W19669610022014 @default.
- W1966961002 countsByYear W19669610022015 @default.
- W1966961002 countsByYear W19669610022016 @default.
- W1966961002 countsByYear W19669610022017 @default.
- W1966961002 countsByYear W19669610022018 @default.
- W1966961002 countsByYear W19669610022019 @default.
- W1966961002 countsByYear W19669610022020 @default.
- W1966961002 countsByYear W19669610022021 @default.
- W1966961002 countsByYear W19669610022022 @default.
- W1966961002 countsByYear W19669610022023 @default.
- W1966961002 crossrefType "journal-article" @default.
- W1966961002 hasAuthorship W1966961002A5011800585 @default.
- W1966961002 hasAuthorship W1966961002A5042894117 @default.
- W1966961002 hasAuthorship W1966961002A5052978566 @default.
- W1966961002 hasAuthorship W1966961002A5055322102 @default.
- W1966961002 hasAuthorship W1966961002A5057996602 @default.
- W1966961002 hasAuthorship W1966961002A5064733011 @default.
- W1966961002 hasAuthorship W1966961002A5071557196 @default.
- W1966961002 hasAuthorship W1966961002A5074370028 @default.
- W1966961002 hasBestOaLocation W19669610024 @default.
- W1966961002 hasConcept C126322002 @default.
- W1966961002 hasConcept C134018914 @default.
- W1966961002 hasConcept C170493617 @default.
- W1966961002 hasConcept C185592680 @default.
- W1966961002 hasConcept C203014093 @default.
- W1966961002 hasConcept C2776217527 @default.
- W1966961002 hasConcept C2777193897 @default.
- W1966961002 hasConcept C2778938600 @default.
- W1966961002 hasConcept C2779357093 @default.