FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966961951> ?p ?o ?g. }

• W1966961951 abstract "Gene targeting in embryonic stem cells (ESCs) has become the principal technology for generating knockout models. Although numerous studies have predicted that the disruption of p53 leads to increased developmental anomalies and malignancies, most p53 knockout mice develop normally. Therefore, the role of p53 in animal development was examined using rat knockout models. Conventionally generated homozygous KO males developed normally, whereas females rarely survived due to neural tube defects. Mutant chimeras generated via blastocyst injection with p53-null ESCs exhibited high rates of embryonic lethality in both sexes. This phenotype could be observed in one month by the use of zinc-finger nucleases. The p53-null ESCs were resistant to apoptosis and differentiation and exhibited severe chromosome instabilities in the chimera-contributed cells, suggesting an essential role for p53 in maintaining ESC quality and genomic integrity. These results demonstrate that p53 functions as a guardian of embryogenesis in the rats." @default.
• W1966961951 created "2016-06-24" @default.
• W1966961951 creator A5006406850 @default.
• W1966961951 creator A5017837826 @default.
• W1966961951 date "2012-12-10" @default.
• W1966961951 modified "2023-10-03" @default.
• W1966961951 title "Two distinct knockout approaches highlight a critical role for p53 in rat development" @default.
• W1966961951 cites W1868067250 @default.
• W1966961951 cites W1963629394 @default.
• W1966961951 cites W1966198395 @default.
• W1966961951 cites W1972434468 @default.
• W1966961951 cites W1974039964 @default.
• W1966961951 cites W1976878409 @default.
• W1966961951 cites W1979209918 @default.
• W1966961951 cites W1983294478 @default.
• W1966961951 cites W1984353621 @default.
• W1966961951 cites W1990001503 @default.
• W1966961951 cites W1998841485 @default.
• W1966961951 cites W2000658520 @default.
• W1966961951 cites W2014365914 @default.
• W1966961951 cites W2016326399 @default.
• W1966961951 cites W2019262146 @default.
• W1966961951 cites W2020458486 @default.
• W1966961951 cites W2021920476 @default.
• W1966961951 cites W2026322742 @default.
• W1966961951 cites W2036632122 @default.
• W1966961951 cites W2054857432 @default.
• W1966961951 cites W2056079046 @default.
• W1966961951 cites W2063668515 @default.
• W1966961951 cites W2071392786 @default.
• W1966961951 cites W2074364455 @default.
• W1966961951 cites W2075857997 @default.
• W1966961951 cites W2081620485 @default.
• W1966961951 cites W2088931058 @default.
• W1966961951 cites W2093611896 @default.
• W1966961951 cites W2096592632 @default.
• W1966961951 cites W2105046145 @default.
• W1966961951 cites W2110722443 @default.
• W1966961951 cites W2111920812 @default.
• W1966961951 cites W2126679757 @default.
• W1966961951 cites W2153130017 @default.
• W1966961951 cites W2154679217 @default.
• W1966961951 cites W2159199900 @default.
• W1966961951 cites W2262171064 @default.
• W1966961951 cites W2413526631 @default.
• W1966961951 doi "https://doi.org/10.1038/srep00945" @default.
• W1966961951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3517977" @default.
• W1966961951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23230510" @default.
• W1966961951 hasPublicationYear "2012" @default.
• W1966961951 type Work @default.
• W1966961951 sameAs 1966961951 @default.
• W1966961951 citedByCount "14" @default.
• W1966961951 countsByYear W19669619512014 @default.
• W1966961951 countsByYear W19669619512015 @default.
• W1966961951 countsByYear W19669619512016 @default.
• W1966961951 countsByYear W19669619512017 @default.
• W1966961951 countsByYear W19669619512019 @default.
• W1966961951 countsByYear W19669619512020 @default.
• W1966961951 countsByYear W19669619512021 @default.
• W1966961951 countsByYear W19669619512022 @default.
• W1966961951 crossrefType "journal-article" @default.
• W1966961951 hasAuthorship W1966961951A5006406850 @default.
• W1966961951 hasAuthorship W1966961951A5017837826 @default.
• W1966961951 hasBestOaLocation W19669619511 @default.
• W1966961951 hasConcept C104317684 @default.
• W1966961951 hasConcept C111829913 @default.
• W1966961951 hasConcept C127716648 @default.
• W1966961951 hasConcept C143065580 @default.
• W1966961951 hasConcept C145103041 @default.
• W1966961951 hasConcept C164659718 @default.
• W1966961951 hasConcept C182704531 @default.
• W1966961951 hasConcept C196843134 @default.
• W1966961951 hasConcept C2778177303 @default.
• W1966961951 hasConcept C30278631 @default.
• W1966961951 hasConcept C502942594 @default.
• W1966961951 hasConcept C54355233 @default.
• W1966961951 hasConcept C77957584 @default.
• W1966961951 hasConcept C86803240 @default.
• W1966961951 hasConcept C87073359 @default.
• W1966961951 hasConcept C95444343 @default.
• W1966961951 hasConceptScore W1966961951C104317684 @default.
• W1966961951 hasConceptScore W1966961951C111829913 @default.
• W1966961951 hasConceptScore W1966961951C127716648 @default.
• W1966961951 hasConceptScore W1966961951C143065580 @default.
• W1966961951 hasConceptScore W1966961951C145103041 @default.
• W1966961951 hasConceptScore W1966961951C164659718 @default.
• W1966961951 hasConceptScore W1966961951C182704531 @default.
• W1966961951 hasConceptScore W1966961951C196843134 @default.
• W1966961951 hasConceptScore W1966961951C2778177303 @default.
• W1966961951 hasConceptScore W1966961951C30278631 @default.
• W1966961951 hasConceptScore W1966961951C502942594 @default.
• W1966961951 hasConceptScore W1966961951C54355233 @default.
• W1966961951 hasConceptScore W1966961951C77957584 @default.
• W1966961951 hasConceptScore W1966961951C86803240 @default.
• W1966961951 hasConceptScore W1966961951C87073359 @default.
• W1966961951 hasConceptScore W1966961951C95444343 @default.
• W1966961951 hasIssue "1" @default.
• W1966961951 hasLocation W19669619511 @default.
• W1966961951 hasLocation W19669619512 @default.
• W1966961951 hasLocation W19669619513 @default.

• next