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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966972007> ?p ?o ?g. }

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• W1966972007 abstract "A class of hybrid molecules which we term 'reversed chloroquines' (RCQs) was designed, and a prototype molecule, N'-(7-chloroquinolin-4-yl)-N-[3-(10,11-dihydrodibenzo[b,f]azepin-5-yl)propyl]-N-methylpropane-1,3-diamine (1), was synthesized and tested against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. An in vitro assay against the two strains indicated that 1 was effective at low-nM concentrations against both strains. A preliminary study in mice demonstrated oral efficacy against P. chabaudi and the absence of obvious toxicity. The RCQ approach therefore appears to be feasible." @default.
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• W1966972007 date "2006-08-12" @default.
• W1966972007 modified "2023-10-14" @default.
• W1966972007 title "A Chloroquine-like Molecule Designed to Reverse Resistance in <i>Plasmodium falciparum</i>" @default.
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• W1966972007 doi "https://doi.org/10.1021/jm060399n" @default.
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