FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966975029> ?p ?o ?g. }

• W1966975029 endingPage "550" @default.
• W1966975029 startingPage "543" @default.
• W1966975029 abstract "Factor VIII-related antigen (FVIII-RA)-positive microvessel areas were measured by both immunohistochemistry and computerized image analysis in patients with active multiple myeloma (MM), nonactive MM, and monoclonal gammopathies of undetermined significance (MGUS). A five-to sixfold larger area was found in patients with active MM compared to the other two groups. Aquaporin 1 (AQP1)-positive microvessel areas, measured with the same techniques on adjacent tissue sections, were also increased in active MM, and tended to be larger than and closely correlated with the FVIII-RA areas. Numerous mast cells were found in the bone marrow of active MM patients, and counts were strictly correlated with the microvessel density. The conditioned medium (CM) of bone marrow plasma cells from active MM patients stimulated endothelial cell proliferation and chemotaxis, monocyte chemotaxis, and angiogenesis in vivo (assessed by the chick embryo chorioallantoic membrane [CAM] system) more strongly and frequently than the CM of patients with nonactive MM and MGUS. Immunoassay of plasma cell lysates gave significantly higher levels of fibroblast growth factor-2 (FGF-2) in patients with active MM than in the other two groups, and a neutralizing anti-FGF-2 antibody inhibited by 46% to 68% the biological activity exerted by the CM in vitro and in the CAM. In situ hybridization of bone marrow plasma cells and zymography of CM showed that patients with active MM express higher levels of matrix metalloproteinase-2 (MMP-2) mRNA and protein than those with nonactive MM and MGUS, whereas MMP-9 expression and secretion overlapped in all groups. Overall data indicate that patients with active MM represent the vascular phase of plasma cell tumors that is induced, at least partly, through FGF-2 and MMP-2. Mast cells possibly contribute to the vascular phase via angiogenic factors in their secretory granules. Both angiogenesis and MMP-2 secretion can account for intramedullary and extramedullary spreading of plasma cells in patients with active MM." @default.
• W1966975029 created "2016-06-24" @default.
• W1966975029 creator A5012195468 @default.
• W1966975029 creator A5054370212 @default.
• W1966975029 creator A5055332109 @default.
• W1966975029 creator A5072050682 @default.
• W1966975029 creator A5085075000 @default.
• W1966975029 date "2001-12-01" @default.
• W1966975029 modified "2023-10-16" @default.
• W1966975029 title "Bone marrow angiogenesis in patients with active multiple myeloma" @default.
• W1966975029 cites W1495287184 @default.
• W1966975029 cites W1522278345 @default.
• W1966975029 cites W1524146737 @default.
• W1966975029 cites W1552949608 @default.
• W1966975029 cites W1580184585 @default.
• W1966975029 cites W1587762493 @default.
• W1966975029 cites W1777794242 @default.
• W1966975029 cites W1896782101 @default.
• W1966975029 cites W1906416848 @default.
• W1966975029 cites W1964417650 @default.
• W1966975029 cites W1966213291 @default.
• W1966975029 cites W1966598311 @default.
• W1966975029 cites W1988605844 @default.
• W1966975029 cites W1992102357 @default.
• W1966975029 cites W1996132190 @default.
• W1966975029 cites W1999067029 @default.
• W1966975029 cites W2004769542 @default.
• W1966975029 cites W2019981138 @default.
• W1966975029 cites W2047310850 @default.
• W1966975029 cites W2047558750 @default.
• W1966975029 cites W2075825850 @default.
• W1966975029 cites W2088111660 @default.
• W1966975029 cites W2117834514 @default.
• W1966975029 cites W2127217689 @default.
• W1966975029 cites W2159679541 @default.
• W1966975029 cites W2294287567 @default.
• W1966975029 cites W2417466616 @default.
• W1966975029 doi "https://doi.org/10.1016/s0093-7754(01)90022-3" @default.
• W1966975029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11740807" @default.
• W1966975029 hasPublicationYear "2001" @default.
• W1966975029 type Work @default.
• W1966975029 sameAs 1966975029 @default.
• W1966975029 citedByCount "81" @default.
• W1966975029 countsByYear W19669750292012 @default.
• W1966975029 countsByYear W19669750292013 @default.
• W1966975029 countsByYear W19669750292014 @default.
• W1966975029 countsByYear W19669750292015 @default.
• W1966975029 countsByYear W19669750292016 @default.
• W1966975029 countsByYear W19669750292017 @default.
• W1966975029 countsByYear W19669750292018 @default.
• W1966975029 countsByYear W19669750292019 @default.
• W1966975029 countsByYear W19669750292020 @default.
• W1966975029 countsByYear W19669750292022 @default.
• W1966975029 countsByYear W19669750292023 @default.
• W1966975029 crossrefType "journal-article" @default.
• W1966975029 hasAuthorship W1966975029A5012195468 @default.
• W1966975029 hasAuthorship W1966975029A5054370212 @default.
• W1966975029 hasAuthorship W1966975029A5055332109 @default.
• W1966975029 hasAuthorship W1966975029A5072050682 @default.
• W1966975029 hasAuthorship W1966975029A5085075000 @default.
• W1966975029 hasConcept C126322002 @default.
• W1966975029 hasConcept C142724271 @default.
• W1966975029 hasConcept C2778271429 @default.
• W1966975029 hasConcept C2780007613 @default.
• W1966975029 hasConcept C2780394083 @default.
• W1966975029 hasConcept C71924100 @default.
• W1966975029 hasConcept C97230052 @default.
• W1966975029 hasConceptScore W1966975029C126322002 @default.
• W1966975029 hasConceptScore W1966975029C142724271 @default.
• W1966975029 hasConceptScore W1966975029C2778271429 @default.
• W1966975029 hasConceptScore W1966975029C2780007613 @default.
• W1966975029 hasConceptScore W1966975029C2780394083 @default.
• W1966975029 hasConceptScore W1966975029C71924100 @default.
• W1966975029 hasConceptScore W1966975029C97230052 @default.
• W1966975029 hasIssue "6" @default.
• W1966975029 hasLocation W19669750291 @default.
• W1966975029 hasLocation W19669750292 @default.
• W1966975029 hasOpenAccess W1966975029 @default.
• W1966975029 hasPrimaryLocation W19669750291 @default.
• W1966975029 hasRelatedWork W128091214 @default.
• W1966975029 hasRelatedWork W1510386426 @default.
• W1966975029 hasRelatedWork W1968490641 @default.
• W1966975029 hasRelatedWork W2058934794 @default.
• W1966975029 hasRelatedWork W2325362314 @default.
• W1966975029 hasRelatedWork W2350091356 @default.
• W1966975029 hasRelatedWork W2359896480 @default.
• W1966975029 hasRelatedWork W2373002200 @default.
• W1966975029 hasRelatedWork W2404470527 @default.
• W1966975029 hasRelatedWork W70240196 @default.
• W1966975029 hasVolume "28" @default.
• W1966975029 isParatext "false" @default.
• W1966975029 isRetracted "false" @default.
• W1966975029 magId "1966975029" @default.
• W1966975029 workType "article" @default.