FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966976593> ?p ?o ?g. }

• W1966976593 endingPage "388" @default.
• W1966976593 startingPage "379" @default.
• W1966976593 abstract "Nitric oxide (NO) plays an important role in inflammation and also in multiple stages of carcinogenesis. We investigated the effects of various tea polyphenols, including theaflavin, a mixture of theaflavin-3-gallate and theaflavin-3′-gallate, theaflavin-3,3′-digallate, thearubigin, and (−)-epigallocatechin-3-gallate on the induction of NO synthase in lipopolysaccharide-activated murine macrophages, RAW 264.7 cells. Theaflavin-3,3′-digallate was found to be stronger than (−)-epigallocatechin-3-gallate in inhibiting NO generation and inducible NO synthase protein in activated macrophages, while theaflavin, a mixture of theaflavin-3-gallate and theaflavin-3′-gallate and thearubigin were less effective. Inhibition of NO production was observed when cells were cotreated with theaflavin-3,3′-digallate and lipopolysaccharide. Western blot and reverse transcriptase-polymerase chain reaction (RT-PCR) analyses demonstrated that significantly reduced 130-kDa protein and mRNA levels of inducible NO synthase were expressed in lipopolysacchride-activated macrophages with theaflavin-3,3′-digallate, compared to those without theaflavin-3,3′-digallate. Electrophoretic mobility shift assay (EMSA) indicated that theaflavin-3,3′-digallate blocked the activation of nuclear factor κB (NF-κB), a transcription factor necessary for inducible NO synthase induction. Theaflavin-3,3′-digallate also blocked phosphorylation of IκB from cytosolic fraction and reduced lipopolysacchride-induced nuclear accumulation of transcription factor NF-κB p65 and p50 subunits. These results suggest that theaflavin-3,3′-digallate decreases the protein levels of inducible NO synthase by reducing the expression of inducible NO synthase mRNA, and the reduction could be via preventing the activation of NF-κB, thereby inhibiting the induction of inducible NO synthase transcription. It was also demonstrated that the gallic acid moiety of theaflavin-3,3′-digallate is essential for their potent anti-inflammation activity." @default.
• W1966976593 created "2016-06-24" @default.
• W1966976593 creator A5021737826 @default.
• W1966976593 creator A5036062527 @default.
• W1966976593 creator A5041417481 @default.
• W1966976593 creator A5065302416 @default.
• W1966976593 creator A5080392236 @default.
• W1966976593 date "1999-02-01" @default.
• W1966976593 modified "2023-10-15" @default.
• W1966976593 title "Theaflavin-3,3′-digallate from black tea blocks the nitric oxide synthase by down-regulating the activation of NF-κB in macrophages" @default.
• W1966976593 cites W1587566573 @default.
• W1966976593 cites W1591881963 @default.
• W1966976593 cites W1822061653 @default.
• W1966976593 cites W1928310803 @default.
• W1966976593 cites W1964253967 @default.
• W1966976593 cites W1970190338 @default.
• W1966976593 cites W1975215292 @default.
• W1966976593 cites W1975982125 @default.
• W1966976593 cites W1978253058 @default.
• W1966976593 cites W1979230311 @default.
• W1966976593 cites W1983668987 @default.
• W1966976593 cites W1985272877 @default.
• W1966976593 cites W1986093516 @default.
• W1966976593 cites W198738073 @default.
• W1966976593 cites W2017487826 @default.
• W1966976593 cites W2020712752 @default.
• W1966976593 cites W2023772557 @default.
• W1966976593 cites W2030592815 @default.
• W1966976593 cites W2031147772 @default.
• W1966976593 cites W2031377838 @default.
• W1966976593 cites W2053209378 @default.
• W1966976593 cites W2054794305 @default.
• W1966976593 cites W2058137293 @default.
• W1966976593 cites W2077641692 @default.
• W1966976593 cites W2078314268 @default.
• W1966976593 cites W2081078817 @default.
• W1966976593 cites W2081144322 @default.
• W1966976593 cites W2084833952 @default.
• W1966976593 cites W2124690619 @default.
• W1966976593 cites W2141670884 @default.
• W1966976593 cites W2145208713 @default.
• W1966976593 cites W2152098493 @default.
• W1966976593 cites W2166781237 @default.
• W1966976593 cites W4294216491 @default.
• W1966976593 cites W4322715279 @default.
• W1966976593 doi "https://doi.org/10.1016/s0014-2999(98)00953-4" @default.
• W1966976593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10079014" @default.
• W1966976593 hasPublicationYear "1999" @default.
• W1966976593 type Work @default.
• W1966976593 sameAs 1966976593 @default.
• W1966976593 citedByCount "147" @default.
• W1966976593 countsByYear W19669765932012 @default.
• W1966976593 countsByYear W19669765932013 @default.
• W1966976593 countsByYear W19669765932014 @default.
• W1966976593 countsByYear W19669765932015 @default.
• W1966976593 countsByYear W19669765932016 @default.
• W1966976593 countsByYear W19669765932017 @default.
• W1966976593 countsByYear W19669765932018 @default.
• W1966976593 countsByYear W19669765932019 @default.
• W1966976593 countsByYear W19669765932020 @default.
• W1966976593 countsByYear W19669765932021 @default.
• W1966976593 countsByYear W19669765932022 @default.
• W1966976593 countsByYear W19669765932023 @default.
• W1966976593 crossrefType "journal-article" @default.
• W1966976593 hasAuthorship W1966976593A5021737826 @default.
• W1966976593 hasAuthorship W1966976593A5036062527 @default.
• W1966976593 hasAuthorship W1966976593A5041417481 @default.
• W1966976593 hasAuthorship W1966976593A5065302416 @default.
• W1966976593 hasAuthorship W1966976593A5080392236 @default.
• W1966976593 hasConcept C153911025 @default.
• W1966976593 hasConcept C181199279 @default.
• W1966976593 hasConcept C185592680 @default.
• W1966976593 hasConcept C2777622882 @default.
• W1966976593 hasConcept C2778004101 @default.
• W1966976593 hasConcept C2780487065 @default.
• W1966976593 hasConcept C55493867 @default.
• W1966976593 hasConcept C70899900 @default.
• W1966976593 hasConcept C86803240 @default.
• W1966976593 hasConceptScore W1966976593C153911025 @default.
• W1966976593 hasConceptScore W1966976593C181199279 @default.
• W1966976593 hasConceptScore W1966976593C185592680 @default.
• W1966976593 hasConceptScore W1966976593C2777622882 @default.
• W1966976593 hasConceptScore W1966976593C2778004101 @default.
• W1966976593 hasConceptScore W1966976593C2780487065 @default.
• W1966976593 hasConceptScore W1966976593C55493867 @default.
• W1966976593 hasConceptScore W1966976593C70899900 @default.
• W1966976593 hasConceptScore W1966976593C86803240 @default.
• W1966976593 hasIssue "2-3" @default.
• W1966976593 hasLocation W19669765931 @default.
• W1966976593 hasLocation W19669765932 @default.
• W1966976593 hasOpenAccess W1966976593 @default.
• W1966976593 hasPrimaryLocation W19669765931 @default.
• W1966976593 hasRelatedWork W1850986032 @default.
• W1966976593 hasRelatedWork W1968721630 @default.
• W1966976593 hasRelatedWork W2026371618 @default.
• W1966976593 hasRelatedWork W2029732200 @default.
• W1966976593 hasRelatedWork W2065079376 @default.
• W1966976593 hasRelatedWork W2080203695 @default.

• next