FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966976621> ?p ?o ?g. }

• W1966976621 endingPage "473" @default.
• W1966976621 startingPage "459" @default.
• W1966976621 abstract "This study explores and characterizes the toxicity of two closely related carcinogenic dinitro-pyrenes (DNPs), 1,3-DNP and 1,8-DNP, in human bronchial epithelial BEAS-2B cells and mouse hepatoma Hepa1c1c7 cells. Neither 1,3-DNP nor 1,8-DNP (3–30 μM) induced cell death in BEAS-2B cells. In Hepa1c1c7 cells only 1,3-DNP (10–30 μM) induced a mixture of apoptotic and necrotic cell death after 24 h. Both compounds increased the level of reactive oxygen species (ROS) in BEAS-2B as measured by CM-H2DCFDA-fluorescence. A corresponding increase in oxidative damage to DNA was revealed by the formamidopyrimidine-DNA glycosylase (fpg)-modified comet assay. Without fpg, DNP-induced DNA damage detected by the comet assay was only found in Hepa1c1c7 cells. Only 1,8-DNP formed DNA adduct measured by 32P-postlabelling. In Hepa1c1c cells, 1,8-DNP induced phosphorylation of H2AX (γH2AX) and p53 at a lower concentration than 1,3-DNP and there was no direct correlation between DNA damage/DNA damage response (DR) and induced cytotoxicity. On the other hand, 1,3-DNP-induced apoptosis was inhibited by pifithrin-α, an inhibitor of p53 transcriptional activity. Furthermore, 1,3-DNP triggered an unfolded protein response (UPR), as measured by an increased expression of CHOP, ATF4 and XBP1. Thus, other types of damage possibly linked to endoplasmic reticulum (ER)-stress and/or UPR could be involved in the induced apoptosis. Our results suggest that the stronger carcinogenic potency of 1,8-DNP compared to 1,3-DNP is linked to its higher genotoxic effects. This in combination with its lower potency to induce cell death may increase the probability of causing mutations." @default.
• W1966976621 created "2016-06-24" @default.
• W1966976621 creator A5004246712 @default.
• W1966976621 creator A5006674415 @default.
• W1966976621 creator A5010012417 @default.
• W1966976621 creator A5014466291 @default.
• W1966976621 creator A5019063695 @default.
• W1966976621 creator A5029460367 @default.
• W1966976621 creator A5033189663 @default.
• W1966976621 creator A5036312951 @default.
• W1966976621 creator A5054061062 @default.
• W1966976621 creator A5067811390 @default.
• W1966976621 creator A5076144513 @default.
• W1966976621 creator A5083028455 @default.
• W1966976621 creator A5087622113 @default.
• W1966976621 date "2014-01-01" @default.
• W1966976621 modified "2023-10-18" @default.
• W1966976621 title "Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene" @default.
• W1966976621 cites W1500106790 @default.
• W1966976621 cites W1563520473 @default.
• W1966976621 cites W1570902901 @default.
• W1966976621 cites W1964622938 @default.
• W1966976621 cites W1972703497 @default.
• W1966976621 cites W1975793610 @default.
• W1966976621 cites W1983796264 @default.
• W1966976621 cites W1984680475 @default.
• W1966976621 cites W1986843840 @default.
• W1966976621 cites W1988435321 @default.
• W1966976621 cites W1989652405 @default.
• W1966976621 cites W1990409661 @default.
• W1966976621 cites W1993213162 @default.
• W1966976621 cites W1993619636 @default.
• W1966976621 cites W1995741673 @default.
• W1966976621 cites W1996808794 @default.
• W1966976621 cites W1996849268 @default.
• W1966976621 cites W2000541477 @default.
• W1966976621 cites W2004981017 @default.
• W1966976621 cites W2009984834 @default.
• W1966976621 cites W2010199771 @default.
• W1966976621 cites W2013736051 @default.
• W1966976621 cites W2014781687 @default.
• W1966976621 cites W2019573217 @default.
• W1966976621 cites W2023262295 @default.
• W1966976621 cites W2030445630 @default.
• W1966976621 cites W2035463605 @default.
• W1966976621 cites W2045501667 @default.
• W1966976621 cites W2046374080 @default.
• W1966976621 cites W2049383029 @default.
• W1966976621 cites W2051059335 @default.
• W1966976621 cites W2053591572 @default.
• W1966976621 cites W2055084808 @default.
• W1966976621 cites W2057036781 @default.
• W1966976621 cites W2057121763 @default.
• W1966976621 cites W2058631780 @default.
• W1966976621 cites W2061795391 @default.
• W1966976621 cites W2063222926 @default.
• W1966976621 cites W2066725924 @default.
• W1966976621 cites W2069182261 @default.
• W1966976621 cites W2069364842 @default.
• W1966976621 cites W2071204630 @default.
• W1966976621 cites W2073556498 @default.
• W1966976621 cites W2074471441 @default.
• W1966976621 cites W2077161346 @default.
• W1966976621 cites W2077280643 @default.
• W1966976621 cites W2079070439 @default.
• W1966976621 cites W2079255752 @default.
• W1966976621 cites W2083357194 @default.
• W1966976621 cites W2085933321 @default.
• W1966976621 cites W2089351142 @default.
• W1966976621 cites W2089826384 @default.
• W1966976621 cites W2089886478 @default.
• W1966976621 cites W2091973582 @default.
• W1966976621 cites W2098394839 @default.
• W1966976621 cites W2113895307 @default.
• W1966976621 cites W2114230669 @default.
• W1966976621 cites W2114733293 @default.
• W1966976621 cites W2124330179 @default.
• W1966976621 cites W2135325091 @default.
• W1966976621 cites W2137315428 @default.
• W1966976621 cites W2142201907 @default.
• W1966976621 cites W2149845523 @default.
• W1966976621 cites W2151873903 @default.
• W1966976621 cites W2156844656 @default.
• W1966976621 cites W2158172811 @default.
• W1966976621 cites W2165102632 @default.
• W1966976621 cites W2170622332 @default.
• W1966976621 cites W2977664922 @default.
• W1966976621 cites W4232041191 @default.
• W1966976621 cites W4297874907 @default.
• W1966976621 cites W60311618 @default.
• W1966976621 cites W70886065 @default.
• W1966976621 doi "https://doi.org/10.1016/j.toxrep.2014.07.009" @default.
• W1966976621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4547165" @default.
• W1966976621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28962260" @default.
• W1966976621 hasPublicationYear "2014" @default.
• W1966976621 type Work @default.
• W1966976621 sameAs 1966976621 @default.
• W1966976621 citedByCount "3" @default.

• next