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- W1966978071 abstract "A major contemporary concern in developing effective liposome–nanoparticle hybrids is the present inclusion size limitation of nanoparticles between vesicle bilayers, which is considered to be around 6.5 nm in diameter. In this article, we present experimental observations backed by theoretical considerations which show that greater structures can be incorporated within vesicle membranes by promoting the clustering of nanoparticles before liposome formation. Cryo-transmission electron microscopy and cryo-electron tomography confirm these observations at unprecedented detail and underpin that the liposome membranes can accommodate flexible structures of up to 60 nm in size. These results imply that this material is more versatile in terms of inclusion capabilities and consequently widens the opportunities in developing multivalent vesicles for nanobiotechnology applications." @default.
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- W1966978071 date "2014-03-13" @default.
- W1966978071 modified "2023-10-03" @default.
- W1966978071 title "Insertion of Nanoparticle Clusters into Vesicle Bilayers" @default.
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- W1966978071 doi "https://doi.org/10.1021/nn406349z" @default.
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