FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966980673> ?p ?o ?g. }

• W1966980673 endingPage "76" @default.
• W1966980673 startingPage "68" @default.
• W1966980673 abstract "Exposure to low levels of cadmium reduces fertility. In male mice spermatogenesis is highly sensitive to cadmium, whereas in females the peri-implantation period of pregnancy is sensitive. To examine the potential roles of the cadmium-binding protein, metallothionein (MT), in the reproductive toxicology of cadmium, we examined a transgenic mouse strain that overexpresses metallothionein-I (MT-I). These mice had dramatically increased steady-state levels of MT-I mRNA and MT in the testes and in the female reproductive tract during the peri-implantation period of pregnancy, and this overexpression occurred in a cell-specific and temporally regulated manner similar to that of the endogenous MT-I gene. Transgenic and control males were injected with cadmium, and the histology of the testes was examined. An injection of 7.5 mumol Cd/kg had no effect on histology of the testes in either transgenic or control mice. In contrast, an injection of 10 mumol Cd/kg caused rapid changes in the histology of the testes and resulted in pronounced testicular necrosis in both control and transgenic mice. Female transgenic and control mice were mated and then injected with cadmium (30-45 mumol Cd/kg) on the day of blastocyst implantation (day 4). In both of these groups, injection of cadmium reduced pregnancy rate, and no dramatic protection was afforded by maternal and/or embryonic overexpression of MT. Thus, overexpression of MT-I does not significantly protect against either of these cadmium-induced effects on fertility." @default.
• W1966980673 created "2016-06-24" @default.
• W1966980673 creator A5025588629 @default.
• W1966980673 creator A5033550773 @default.
• W1966980673 creator A5054997692 @default.
• W1966980673 creator A5055765486 @default.
• W1966980673 creator A5090334632 @default.
• W1966980673 date "1996-01-01" @default.
• W1966980673 modified "2023-10-18" @default.
• W1966980673 title "Analysis of the effects of overexpression of metallothionein-I in transgenic mice on the reproductive toxicology of cadmium." @default.
• W1966980673 cites W1248664554 @default.
• W1966980673 cites W1503331387 @default.
• W1966980673 cites W1538199768 @default.
• W1966980673 cites W1550441131 @default.
• W1966980673 cites W1554793449 @default.
• W1966980673 cites W1582846107 @default.
• W1966980673 cites W1895321601 @default.
• W1966980673 cites W1964790813 @default.
• W1966980673 cites W1978371955 @default.
• W1966980673 cites W1980921634 @default.
• W1966980673 cites W1985712270 @default.
• W1966980673 cites W1987415108 @default.
• W1966980673 cites W1992256486 @default.
• W1966980673 cites W1994238315 @default.
• W1966980673 cites W2002262958 @default.
• W1966980673 cites W2003325995 @default.
• W1966980673 cites W2013794283 @default.
• W1966980673 cites W2021008729 @default.
• W1966980673 cites W2024878014 @default.
• W1966980673 cites W2025896373 @default.
• W1966980673 cites W2031121245 @default.
• W1966980673 cites W2031255424 @default.
• W1966980673 cites W2033751799 @default.
• W1966980673 cites W2036394095 @default.
• W1966980673 cites W2045890708 @default.
• W1966980673 cites W2050079481 @default.
• W1966980673 cites W2050615089 @default.
• W1966980673 cites W2051427804 @default.
• W1966980673 cites W2053208311 @default.
• W1966980673 cites W2054530448 @default.
• W1966980673 cites W2054637846 @default.
• W1966980673 cites W2058953608 @default.
• W1966980673 cites W2061195448 @default.
• W1966980673 cites W2066160869 @default.
• W1966980673 cites W2067450828 @default.
• W1966980673 cites W2069514871 @default.
• W1966980673 cites W2072826166 @default.
• W1966980673 cites W2091305184 @default.
• W1966980673 cites W2098924542 @default.
• W1966980673 cites W2103672917 @default.
• W1966980673 cites W2108373851 @default.
• W1966980673 cites W2134812217 @default.
• W1966980673 cites W2145050646 @default.
• W1966980673 cites W2153477671 @default.
• W1966980673 cites W2155601610 @default.
• W1966980673 cites W2156472678 @default.
• W1966980673 cites W2162288856 @default.
• W1966980673 cites W2203350225 @default.
• W1966980673 cites W2214671441 @default.
• W1966980673 cites W2223559671 @default.
• W1966980673 cites W2253644836 @default.
• W1966980673 cites W2273089598 @default.
• W1966980673 cites W2321378101 @default.
• W1966980673 cites W2403189072 @default.
• W1966980673 cites W2411708258 @default.
• W1966980673 cites W304228639 @default.
• W1966980673 doi "https://doi.org/10.1289/ehp.9610468" @default.
• W1966980673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1469252" @default.
• W1966980673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8834864" @default.
• W1966980673 hasPublicationYear "1996" @default.
• W1966980673 type Work @default.
• W1966980673 sameAs 1966980673 @default.
• W1966980673 citedByCount "56" @default.
• W1966980673 countsByYear W19669806732012 @default.
• W1966980673 countsByYear W19669806732015 @default.
• W1966980673 countsByYear W19669806732016 @default.
• W1966980673 countsByYear W19669806732022 @default.
• W1966980673 countsByYear W19669806732023 @default.
• W1966980673 crossrefType "journal-article" @default.
• W1966980673 hasAuthorship W1966980673A5025588629 @default.
• W1966980673 hasAuthorship W1966980673A5033550773 @default.
• W1966980673 hasAuthorship W1966980673A5054997692 @default.
• W1966980673 hasAuthorship W1966980673A5055765486 @default.
• W1966980673 hasAuthorship W1966980673A5090334632 @default.
• W1966980673 hasBestOaLocation W19669806731 @default.
• W1966980673 hasConcept C102230213 @default.
• W1966980673 hasConcept C104317684 @default.
• W1966980673 hasConcept C123765429 @default.
• W1966980673 hasConcept C126322002 @default.
• W1966980673 hasConcept C134018914 @default.
• W1966980673 hasConcept C141035611 @default.
• W1966980673 hasConcept C16685009 @default.
• W1966980673 hasConcept C178790620 @default.
• W1966980673 hasConcept C185592680 @default.
• W1966980673 hasConcept C196843134 @default.
• W1966980673 hasConcept C20719415 @default.
• W1966980673 hasConcept C2780473477 @default.
• W1966980673 hasConcept C29730261 @default.

• next