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• W1966983485 abstract "Skeletal development involves the coordinated participation of several types of collagen, including both major and minor fibrillar collagens. Although much is known about the major fibrillar collagens, such as types I and II, less is known about the minor fibrillar collagens, and their role in the repair and regeneration of bone has not been extensively studied. To clarify the role of minor fibrillar collagens in Fracture repair, we examined the spatial and temporal expression of mRNAs for pro-α2(V) collagen and pro-α1(XI) collagen in healing fractures in the rat by in situ hybridization and compared their patterns of expression with those Of mRNAs for pro-α1(I) collagen, pro-α1(II) collagen, and osteocalcin. A strong signal for pro-α2(V) was detected in the periosteal osteoprogenitor cells, whereas osteocalcin mRNA was strongly expressed only in the deep layers of the hard callus. The distribution of the pro-α2(V) signal was correlated with that of pro-α1(I) but was mutually exclusive of that of pro-α1(II).The expression of pro-α1(Xl) mRNA was synchronously regulated with that of pro-α1(II) during chondrogenesis in the soft callus. In the hard callus, pro-α1(XI) signal Was found in osteoblastic cells at the site of intramembranous and endochondral ossification. These cells simultaneously expressed pro-α2(V), although they were negative for pro-α1(II). These findings suggest that the, α2(V) collagen chain participates in the formation of the noncartilaginous fibrillar network in the hard callus and preferentially contributes to the initial stage of the intramembranous bone formation. Recent reports have, revealed that type-XI collagen, which had been classified as a cartilage-type collagen, is not necessarily specific for cartilage. The present results advanced this recognition and demonstrated a coexpression of α1(XI) mRNA and α2(V) mRNA in the noncartilaginous tissues in the fracture callus; this suggests the presence of tissue-specific and stage-specific heterotrimers consisting of α1(XI) and α2(V) collagen chains and the association of such hybrid trimers with the major fibrillar collagens in the process of fracture healing." @default.
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• W1966983485 date "1997-09-01" @default.
• W1966983485 modified "2023-10-07" @default.
• W1966983485 title "Spatial and temporal expression of fibril-forming minor collagen genes (types V and XI) during fracture healing" @default.
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• W1966983485 doi "https://doi.org/10.1002/jor.1100150519" @default.
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