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- W1966984952 abstract "1. Two ketal derivatives of α-chlorohydrin, which possess male antifertility activity, have been synthesized labelled with 36Cl. Both are metabolized by the rat to β-chlorolactic acid.2. Neither derivative inhibited the glycolytic enzymes glyceraldehyde 3-phosphate dehydrogenase and triosephosphate isomerase.3. The epoxide glycidol is metabolized to β-chlorolactic acid, presumably by first being converted to α-chlorohydrin.4. It is proposed that the male antifertility actions of these three analogues is due to their biotransformation to α-chlorohydrin, which is then metabolized within mature sperm to a compound which is an inhibitor of glycolysis." @default.
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- W1966984952 date "1980-01-01" @default.
- W1966984952 modified "2023-09-30" @default.
- W1966984952 title "Metabolism of three active analogues of the male antifertility agent α-chlorohydrin in the rat" @default.
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- W1966984952 doi "https://doi.org/10.3109/00498258009033769" @default.
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