Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966988071> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1966988071 endingPage "58" @default.
- W1966988071 startingPage "53" @default.
- W1966988071 abstract "A possible mechanism for fenfluramine-induced pulmonary hypertension has been investigated. Fenfluramine, like chlorphentermine, may inhibit the pulmonary uptake and/or metabolism of 5-hydroxytryptamine (5-HT). This allows more 5-HT to remain in the pulmonary circulation, where it may exert a greater vasoconstrictor action resulting in pulmonary hypertension. Chlorphentermine has been shown to inhibit the uptake and metabolism of 5-HT. The effect of fenfluramine on the pulmonary disposition of [14C]5-HT has been investigated, in comparison with chlorphentermine, using a recirculating isolated perfused rat lung system. The pulmonary disposition of [14C]5-HT was assessed by measuring the change in [14C]5-HT concentration in the perfusion medium during the experiment and at the end, and the concentration in the lung at the end of the experiment. The concentration of 5-hydroxyindoleacetic acid, a metabolite of 5-HT, was measured in perfusate and lung samples. Mean pulmonary clearance of 5-HT for the control lung and lungs challenged with either fenfluramine (2.5 microM) or chlorphentermine (25 microM) was 4.514, 1.316 and 1.007 mL min(-1), respectively (n = 5). The concentration of 5-HT found in the lungs at the end of the experiment for the control and the lungs preloaded with fenfluramine or chlorphentermine was 695.05+/-9.69, 638.65+/-10.27 and 617.3+/-14.38 ng g(-1), respectively. Fenfluramine, like chlorphentermine, inhibited the pulmonary disposition of 5-HT resulting in an elevated perfusate level of 5-HT. This is a possible contributing mechanism for fenfluramine-induced pulmonary hypertension. The effect of fenfluramine was less pronounced than chlorphentermine." @default.
- W1966988071 created "2016-06-24" @default.
- W1966988071 creator A5004006314 @default.
- W1966988071 creator A5050088339 @default.
- W1966988071 date "2000-01-01" @default.
- W1966988071 modified "2023-09-26" @default.
- W1966988071 title "The Effect of Fenfluramine on the Pulmonary Disposition of 5-Hydroxytryptamine in the Isolated Perfused Rat Lung: a Comparison with Chlorphentermine" @default.
- W1966988071 cites W1986886849 @default.
- W1966988071 cites W1987425562 @default.
- W1966988071 cites W1996588278 @default.
- W1966988071 cites W2007268079 @default.
- W1966988071 cites W2014466515 @default.
- W1966988071 cites W2063905407 @default.
- W1966988071 cites W2088079666 @default.
- W1966988071 cites W2138343290 @default.
- W1966988071 cites W2329065056 @default.
- W1966988071 doi "https://doi.org/10.1211/0022357001773689" @default.
- W1966988071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10716603" @default.
- W1966988071 hasPublicationYear "2000" @default.
- W1966988071 type Work @default.
- W1966988071 sameAs 1966988071 @default.
- W1966988071 citedByCount "4" @default.
- W1966988071 countsByYear W19669880712013 @default.
- W1966988071 countsByYear W19669880712021 @default.
- W1966988071 countsByYear W19669880712022 @default.
- W1966988071 crossrefType "journal-article" @default.
- W1966988071 hasAuthorship W1966988071A5004006314 @default.
- W1966988071 hasAuthorship W1966988071A5050088339 @default.
- W1966988071 hasBestOaLocation W19669880711 @default.
- W1966988071 hasConcept C126322002 @default.
- W1966988071 hasConcept C134018914 @default.
- W1966988071 hasConcept C146957229 @default.
- W1966988071 hasConcept C170493617 @default.
- W1966988071 hasConcept C185592680 @default.
- W1966988071 hasConcept C2775864247 @default.
- W1966988071 hasConcept C2777714996 @default.
- W1966988071 hasConcept C2779638493 @default.
- W1966988071 hasConcept C2780930700 @default.
- W1966988071 hasConcept C55493867 @default.
- W1966988071 hasConcept C62231903 @default.
- W1966988071 hasConcept C71924100 @default.
- W1966988071 hasConcept C98274493 @default.
- W1966988071 hasConceptScore W1966988071C126322002 @default.
- W1966988071 hasConceptScore W1966988071C134018914 @default.
- W1966988071 hasConceptScore W1966988071C146957229 @default.
- W1966988071 hasConceptScore W1966988071C170493617 @default.
- W1966988071 hasConceptScore W1966988071C185592680 @default.
- W1966988071 hasConceptScore W1966988071C2775864247 @default.
- W1966988071 hasConceptScore W1966988071C2777714996 @default.
- W1966988071 hasConceptScore W1966988071C2779638493 @default.
- W1966988071 hasConceptScore W1966988071C2780930700 @default.
- W1966988071 hasConceptScore W1966988071C55493867 @default.
- W1966988071 hasConceptScore W1966988071C62231903 @default.
- W1966988071 hasConceptScore W1966988071C71924100 @default.
- W1966988071 hasConceptScore W1966988071C98274493 @default.
- W1966988071 hasIssue "1" @default.
- W1966988071 hasLocation W19669880711 @default.
- W1966988071 hasLocation W19669880712 @default.
- W1966988071 hasOpenAccess W1966988071 @default.
- W1966988071 hasPrimaryLocation W19669880711 @default.
- W1966988071 hasRelatedWork W1558342319 @default.
- W1966988071 hasRelatedWork W2007331371 @default.
- W1966988071 hasRelatedWork W2009035551 @default.
- W1966988071 hasRelatedWork W2012358447 @default.
- W1966988071 hasRelatedWork W2027834137 @default.
- W1966988071 hasRelatedWork W2055572014 @default.
- W1966988071 hasRelatedWork W2074980959 @default.
- W1966988071 hasRelatedWork W2094903580 @default.
- W1966988071 hasRelatedWork W2128286595 @default.
- W1966988071 hasRelatedWork W2432308696 @default.
- W1966988071 hasVolume "52" @default.
- W1966988071 isParatext "false" @default.
- W1966988071 isRetracted "false" @default.
- W1966988071 magId "1966988071" @default.
- W1966988071 workType "article" @default.