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• W1966989983 abstract "The immunomodulatory role of vitamin D in many diseases is well established. However, the relationship between vitamin D status and skin cancers is unclear. In this study, we examined the effect of vitamin D deficiency and sufficiency on VDR, NF-κB, and CD86 in the epidermis of Yucatan microswine tragi. All of these proteins have known roles in the pathogenesis of cutaneous malignancies such as melanoma and non-melanoma skin cancer. There was weaker and less discrete nuclear staining for VDR and weaker CD86 immunoreactivity with patchy membranous expression in the epidermis of vitamin D-deficient compared to vitamin D-sufficient swine. There was no difference in the immunostaining for NF-κB. Since VDR and CD86 expression are decreased in the setting of melanoma and non-melanoma skin cancers, our findings suggest a potential role of vitamin D-deficiency in the progression of skin malignancies." @default.
• W1966989983 created "2016-06-24" @default.
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• W1966989983 date "2014-02-01" @default.
• W1966989983 modified "2023-09-24" @default.
• W1966989983 title "Vitamin D receptor and CD86 expression in the skin of vitamin D-deficient swine" @default.
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• W1966989983 doi "https://doi.org/10.1016/j.yexmp.2013.11.002" @default.
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