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- W1966991885 abstract "Photically evoked afterdischarges (PhAD) recorded from the visual cortex are thalamically coupled hyper synchronous patterns known to be sensitive to changes in level of behavioral arousal. In the present study, parameters of PhAD patterns were examined in lightly restrained rats following incremental injections of various dosages of atropine sulfate. Low doses of atropine increased PhAD occurrence, whereas high doses of atropine suppressed the elicitation of this pattern as compared to saline- and methyl-atropine-treated control animals. A low level of atropine is hypothesized to reduce or stabilize reticular activation of thalamic and cortical neuron pools, thus generating a level of excitation compatible with pronounced PhAD elicitation. Conversely, asynchronous electrocortical patterns produced by high levels of atropine are associated with a physiological substrate that precludes the development of hypersynchronous PhAD bursts." @default.
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- W1966991885 date "1985-06-01" @default.
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- W1966991885 title "Incremental-dose effects of atropine on photic afterdischarge" @default.
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- W1966991885 doi "https://doi.org/10.3758/bf03329877" @default.
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