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• W1966993054 abstract "Three Chinese herbal extracts, Drynaria baronii, Angelica sinensis and Cornus officinalis Sieb. et Zucc (referred to as DB, AS, CO, respectively), were investigated for their possible anti-inflammatory activity. DB, AS and CO inhibited nitric oxide (NO) production by lipopolysaccharide (LPS)-activated mouse macrophage-like RAW264.7 cells. Western blot and RT-PCR analyses demonstrated that this was due to the inhibition of inducible NO synthase (iNOS) expression at both protein and mRNA levels. Electron-spin resonance spectroscopy showed that DB, AS and CO dose-dependently scavenged the NO radical produced by NOC-7 in the presence of carboxy-PTIO. In order to confirm the anti-inflammatory potency, effects on prostaglandin (PG) E₂ production and the expression of enzymes involved in the arachidonic acid pathway were next investigated. DB and CO effectively inhibited the PGE₂ production by LPS-stimulated RAW264.7 cells, although the extent of inhibition of PGE₂ production was slightly lower than that of NO production. AS only marginally inhibited the LPS-stimulated PGE₂ production. DB, AS and CO inhibited cyclooxygenase (COX)-2 expression at both protein and mRNA levels, but to much lesser extents as compared with that for iNOS expression. These data further substantiate the anti-inflammatory potency of DB, AS and CO." @default.
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• W1966993054 date "2004-01-01" @default.
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• W1966993054 title "Do children's intentions to risk take relate to actual risk taking?" @default.
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• W1966993054 doi "https://doi.org/10.1136/ip.2003.003624" @default.
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