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- W1967001078 abstract "Rational design of small focused libraries that are biased toward specific therapeutic targets is currently at the forefront of combinatorial library design. Various structure-based design strategies can be implemented in focused library design when the 3D structure of the target is available through X-ray or NMR determination. This review discusses the major methods and programs specifically developed for the purpose of designing combinatorial libraries under the constraint of the binding site of a biological target, with emphasis on their advantages and disadvantages. Examples of the successful application of these methodologies are highlighted, demonstrating their performances within the practical drug discovery process." @default.
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- W1967001078 date "2002-06-01" @default.
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- W1967001078 title "Structure-based combinatorial library design: methodologies and applications" @default.
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- W1967001078 doi "https://doi.org/10.1016/s1093-3263(01)00147-4" @default.
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