FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967001844> ?p ?o ?g. }

• W1967001844 endingPage "22" @default.
• W1967001844 startingPage "14" @default.
• W1967001844 abstract "Due to their unique properties, the use of nanoparticles (NPs) is expanding; these same properties may affect their potential risk to humans. However, standard methods for genotoxicity assessment may not be adequate for NPs; altered tests reported here have been developed to address perceived inadequacies. The bacterial reverse mutation assay is an essential part of the battery of tests to determine genotoxicity. The utility of this test for assessing NPs is currently questioned, due to negative results seemingly caused by failure of particle uptake. To probe uptake issues, we examined the physical state in different media, dose and time dependent association, uptake and mutagenicity of titanium dioxide (TiO2) NPs in Salmonella typhimurium and Escherichia coli. The NPs suspended in water were characterized using dynamic light scattering, NP tracking analysis and transmission electron microscopy. NP association with bacteria was assessed by flow cytometry. Association was found to be time and dose dependent, with maximal association by 60 min. Therefore mutagenicity was assessed after a 60 min pre-incubation in a miniaturized assay demonstrating enhanced sensitivity. To assess potential indirect effects on bacterial mutagenicity, the effect of TiO2 NPs on the action of standard mutagens or on DNA repair capability was also investigated. TiO2 NPs did not affect mutant yields in standard strains of S. typhimurium or E. coli, including those detecting oxidative damage, using the modified methods. Nor did TiO2 NPs affect the action of standard mutagens or DNA excision repair capability. Despite particle association with the bacteria, subsequent analysis using electron microscopy and energy dispersive x-ray spectroscopy indicated that the NPs were not internalized. This work demonstrates that additional studies, including flow cytometry, are valuable tools for understanding the action of NPs in biological systems." @default.
• W1967001844 created "2016-06-24" @default.
• W1967001844 creator A5015979276 @default.
• W1967001844 creator A5042552832 @default.
• W1967001844 creator A5058873210 @default.
• W1967001844 creator A5069022511 @default.
• W1967001844 creator A5080143248 @default.
• W1967001844 date "2014-07-01" @default.
• W1967001844 modified "2023-09-28" @default.
• W1967001844 title "Assessment of titanium dioxide nanoparticle effects in bacteria: Association, uptake, mutagenicity, co-mutagenicity and DNA repair inhibition" @default.
• W1967001844 cites W1967822639 @default.
• W1967001844 cites W1973628309 @default.
• W1967001844 cites W1973831032 @default.
• W1967001844 cites W1975825403 @default.
• W1967001844 cites W1985191334 @default.
• W1967001844 cites W1991629268 @default.
• W1967001844 cites W1991936143 @default.
• W1967001844 cites W1995276305 @default.
• W1967001844 cites W2002003950 @default.
• W1967001844 cites W2005156172 @default.
• W1967001844 cites W2010713194 @default.
• W1967001844 cites W2024586408 @default.
• W1967001844 cites W2041069117 @default.
• W1967001844 cites W2043637843 @default.
• W1967001844 cites W2057287746 @default.
• W1967001844 cites W2059935374 @default.
• W1967001844 cites W2064679125 @default.
• W1967001844 cites W2065782618 @default.
• W1967001844 cites W2104903627 @default.
• W1967001844 cites W2107283881 @default.
• W1967001844 cites W2124688926 @default.
• W1967001844 cites W2140181820 @default.
• W1967001844 cites W2159942532 @default.
• W1967001844 doi "https://doi.org/10.1016/j.mrgentox.2014.04.008" @default.
• W1967001844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24769488" @default.
• W1967001844 hasPublicationYear "2014" @default.
• W1967001844 type Work @default.
• W1967001844 sameAs 1967001844 @default.
• W1967001844 citedByCount "24" @default.
• W1967001844 countsByYear W19670018442015 @default.
• W1967001844 countsByYear W19670018442016 @default.
• W1967001844 countsByYear W19670018442017 @default.
• W1967001844 countsByYear W19670018442018 @default.
• W1967001844 countsByYear W19670018442019 @default.
• W1967001844 countsByYear W19670018442020 @default.
• W1967001844 countsByYear W19670018442021 @default.
• W1967001844 countsByYear W19670018442022 @default.
• W1967001844 crossrefType "journal-article" @default.
• W1967001844 hasAuthorship W1967001844A5015979276 @default.
• W1967001844 hasAuthorship W1967001844A5042552832 @default.
• W1967001844 hasAuthorship W1967001844A5058873210 @default.
• W1967001844 hasAuthorship W1967001844A5069022511 @default.
• W1967001844 hasAuthorship W1967001844A5080143248 @default.
• W1967001844 hasConcept C104317684 @default.
• W1967001844 hasConcept C117632636 @default.
• W1967001844 hasConcept C12554922 @default.
• W1967001844 hasConcept C134935766 @default.
• W1967001844 hasConcept C143065580 @default.
• W1967001844 hasConcept C143425029 @default.
• W1967001844 hasConcept C178790620 @default.
• W1967001844 hasConcept C185592680 @default.
• W1967001844 hasConcept C191897082 @default.
• W1967001844 hasConcept C192562407 @default.
• W1967001844 hasConcept C2777593239 @default.
• W1967001844 hasConcept C2778910516 @default.
• W1967001844 hasConcept C2778959862 @default.
• W1967001844 hasConcept C2781065037 @default.
• W1967001844 hasConcept C29730261 @default.
• W1967001844 hasConcept C523546767 @default.
• W1967001844 hasConcept C54355233 @default.
• W1967001844 hasConcept C547475151 @default.
• W1967001844 hasConcept C552990157 @default.
• W1967001844 hasConcept C55493867 @default.
• W1967001844 hasConcept C86803240 @default.
• W1967001844 hasConcept C89423630 @default.
• W1967001844 hasConceptScore W1967001844C104317684 @default.
• W1967001844 hasConceptScore W1967001844C117632636 @default.
• W1967001844 hasConceptScore W1967001844C12554922 @default.
• W1967001844 hasConceptScore W1967001844C134935766 @default.
• W1967001844 hasConceptScore W1967001844C143065580 @default.
• W1967001844 hasConceptScore W1967001844C143425029 @default.
• W1967001844 hasConceptScore W1967001844C178790620 @default.
• W1967001844 hasConceptScore W1967001844C185592680 @default.
• W1967001844 hasConceptScore W1967001844C191897082 @default.
• W1967001844 hasConceptScore W1967001844C192562407 @default.
• W1967001844 hasConceptScore W1967001844C2777593239 @default.
• W1967001844 hasConceptScore W1967001844C2778910516 @default.
• W1967001844 hasConceptScore W1967001844C2778959862 @default.
• W1967001844 hasConceptScore W1967001844C2781065037 @default.
• W1967001844 hasConceptScore W1967001844C29730261 @default.
• W1967001844 hasConceptScore W1967001844C523546767 @default.
• W1967001844 hasConceptScore W1967001844C54355233 @default.
• W1967001844 hasConceptScore W1967001844C547475151 @default.
• W1967001844 hasConceptScore W1967001844C552990157 @default.
• W1967001844 hasConceptScore W1967001844C55493867 @default.
• W1967001844 hasConceptScore W1967001844C86803240 @default.
• W1967001844 hasConceptScore W1967001844C89423630 @default.
• W1967001844 hasLocation W19670018441 @default.

• next