FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967002747> ?p ?o ?g. }

• W1967002747 endingPage "1338" @default.
• W1967002747 startingPage "1329" @default.
• W1967002747 abstract "Multidrug resistance mediated by P-glycoprotein (Pgp) or multidrug-resistance-associated protein (MRP) remains a major obstacle for successful treatment of cancer. Inhibition of Pgp and MRP transport is important for high efficacy of anticancer drugs. While several Pgp inhibitors have entered clinical trials, the development of specific MRP1 inhibitors is still in its infancy. In our screening program, we have identified a pyrrolopyrimidine (4) as a novel and selective MRP1 inhibitor. Subsequent SAR work on the 4-position of the template revealed the phenethylpiperazine side chain as a potent replacement of the benzylthio group of the lead molecule. Introduction of groups at the 2-position seems to have no detrimental effect on activity. Modifications to the nitrile group at the 7-position resulted in the identification of analogues with groups, such as amides, with superior pharmacokinetic profiles. In vivo efficacy has been demonstrated by xenograft studies on selected compounds." @default.
• W1967002747 created "2016-06-24" @default.
• W1967002747 creator A5008767349 @default.
• W1967002747 creator A5016984424 @default.
• W1967002747 creator A5028263281 @default.
• W1967002747 creator A5038862070 @default.
• W1967002747 creator A5044462544 @default.
• W1967002747 creator A5044796575 @default.
• W1967002747 creator A5049488273 @default.
• W1967002747 creator A5050062139 @default.
• W1967002747 creator A5050767645 @default.
• W1967002747 creator A5050781087 @default.
• W1967002747 creator A5067595817 @default.
• W1967002747 creator A5071062191 @default.
• W1967002747 creator A5074919249 @default.
• W1967002747 creator A5081964181 @default.
• W1967002747 creator A5082288133 @default.
• W1967002747 creator A5083181294 @default.
• W1967002747 creator A5086136651 @default.
• W1967002747 date "2004-02-07" @default.
• W1967002747 modified "2023-10-15" @default.
• W1967002747 title "Studies on Pyrrolopyrimidines as Selective Inhibitors of Multidrug-Resistance- Associated Protein in Multidrug Resistance" @default.
• W1967002747 cites W1502426706 @default.
• W1967002747 cites W1890023926 @default.
• W1967002747 cites W1997204305 @default.
• W1967002747 cites W2000845178 @default.
• W1967002747 cites W2011722085 @default.
• W1967002747 cites W2012619013 @default.
• W1967002747 cites W2027423224 @default.
• W1967002747 cites W2059293500 @default.
• W1967002747 cites W2093132087 @default.
• W1967002747 cites W2146568308 @default.
• W1967002747 cites W2949407848 @default.
• W1967002747 cites W1996094567 @default.
• W1967002747 doi "https://doi.org/10.1021/jm031011g" @default.
• W1967002747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14998323" @default.
• W1967002747 hasPublicationYear "2004" @default.
• W1967002747 type Work @default.
• W1967002747 sameAs 1967002747 @default.
• W1967002747 citedByCount "69" @default.
• W1967002747 countsByYear W19670027472012 @default.
• W1967002747 countsByYear W19670027472013 @default.
• W1967002747 countsByYear W19670027472014 @default.
• W1967002747 countsByYear W19670027472015 @default.
• W1967002747 countsByYear W19670027472016 @default.
• W1967002747 countsByYear W19670027472017 @default.
• W1967002747 countsByYear W19670027472018 @default.
• W1967002747 countsByYear W19670027472019 @default.
• W1967002747 countsByYear W19670027472020 @default.
• W1967002747 countsByYear W19670027472021 @default.
• W1967002747 countsByYear W19670027472022 @default.
• W1967002747 crossrefType "journal-article" @default.
• W1967002747 hasAuthorship W1967002747A5008767349 @default.
• W1967002747 hasAuthorship W1967002747A5016984424 @default.
• W1967002747 hasAuthorship W1967002747A5028263281 @default.
• W1967002747 hasAuthorship W1967002747A5038862070 @default.
• W1967002747 hasAuthorship W1967002747A5044462544 @default.
• W1967002747 hasAuthorship W1967002747A5044796575 @default.
• W1967002747 hasAuthorship W1967002747A5049488273 @default.
• W1967002747 hasAuthorship W1967002747A5050062139 @default.
• W1967002747 hasAuthorship W1967002747A5050767645 @default.
• W1967002747 hasAuthorship W1967002747A5050781087 @default.
• W1967002747 hasAuthorship W1967002747A5067595817 @default.
• W1967002747 hasAuthorship W1967002747A5071062191 @default.
• W1967002747 hasAuthorship W1967002747A5074919249 @default.
• W1967002747 hasAuthorship W1967002747A5081964181 @default.
• W1967002747 hasAuthorship W1967002747A5082288133 @default.
• W1967002747 hasAuthorship W1967002747A5083181294 @default.
• W1967002747 hasAuthorship W1967002747A5086136651 @default.
• W1967002747 hasConcept C133936738 @default.
• W1967002747 hasConcept C185592680 @default.
• W1967002747 hasConcept C207001950 @default.
• W1967002747 hasConcept C2778707650 @default.
• W1967002747 hasConcept C501593827 @default.
• W1967002747 hasConcept C54355233 @default.
• W1967002747 hasConcept C55493867 @default.
• W1967002747 hasConcept C86803240 @default.
• W1967002747 hasConcept C98274493 @default.
• W1967002747 hasConceptScore W1967002747C133936738 @default.
• W1967002747 hasConceptScore W1967002747C185592680 @default.
• W1967002747 hasConceptScore W1967002747C207001950 @default.
• W1967002747 hasConceptScore W1967002747C2778707650 @default.
• W1967002747 hasConceptScore W1967002747C501593827 @default.
• W1967002747 hasConceptScore W1967002747C54355233 @default.
• W1967002747 hasConceptScore W1967002747C55493867 @default.
• W1967002747 hasConceptScore W1967002747C86803240 @default.
• W1967002747 hasConceptScore W1967002747C98274493 @default.
• W1967002747 hasIssue "6" @default.
• W1967002747 hasLocation W19670027471 @default.
• W1967002747 hasLocation W19670027472 @default.
• W1967002747 hasOpenAccess W1967002747 @default.
• W1967002747 hasPrimaryLocation W19670027471 @default.
• W1967002747 hasRelatedWork W1998956539 @default.
• W1967002747 hasRelatedWork W1999906254 @default.
• W1967002747 hasRelatedWork W2016114543 @default.
• W1967002747 hasRelatedWork W2031866272 @default.
• W1967002747 hasRelatedWork W2074950338 @default.
• W1967002747 hasRelatedWork W2091807474 @default.

• next