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- W1967005118 abstract "The ability of mammalian cytidine deaminases encoded by the APOBEC3 (A3) genes to restrict a broad number of endogenous retroelements and exogenous retroviruses, including murine leukemia virus and human immunodeficiency virus (HIV)-1, is now well established. The RNA editing family member apolipoprotein B (apo B)-editing catalytic subunit 1 (APOBEC1; A1) from a variety of mammalian species, a protein involved in lipid transport and which mediates C-U deamination of mRNA for apo B, has also been shown to modify a range of exogenous retroviruses, but its activity against endogenous retroelements remains unclear. Here, we show in cell culture-based retrotransposition assays that A1 family proteins from multiple mammalian species can also reduce the mobility and infectivity potential of LINE-1 (long interspersed nucleotide sequence-1, L1) and long-terminal repeats (LTRs) retrotransposons (or endogenous retroviruses), such as murine intracisternal A-particle (IAP) and MusD sequences. The anti-L1 activity of A1 was mainly mediated by a deamination-independent mechanism, and was not affected by subcellular localization of the proteins. In contrast, the inhibition of LTR-retrotransposons appeared to require the deaminase activity of A1 proteins. Thus, the AID/APOBEC family proteins including A1s employ multiple mechanisms to regulate the mobility of autonomous retrotransposons in several mammalian species." @default.
- W1967005118 created "2016-06-24" @default.
- W1967005118 creator A5003118804 @default.
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- W1967005118 creator A5064313376 @default.
- W1967005118 creator A5072478423 @default.
- W1967005118 date "2011-03-12" @default.
- W1967005118 modified "2023-09-25" @default.
- W1967005118 title "Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons" @default.
- W1967005118 cites W1480928537 @default.
- W1967005118 cites W1509378838 @default.
- W1967005118 cites W1515277671 @default.
- W1967005118 cites W1593014981 @default.
- W1967005118 cites W1680720482 @default.
- W1967005118 cites W1817150603 @default.
- W1967005118 cites W1844787848 @default.
- W1967005118 cites W1944771638 @default.
- W1967005118 cites W1965048581 @default.
- W1967005118 cites W1965141089 @default.
- W1967005118 cites W1966477735 @default.
- W1967005118 cites W1967215131 @default.
- W1967005118 cites W1968772442 @default.
- W1967005118 cites W1973732415 @default.
- W1967005118 cites W1974134624 @default.
- W1967005118 cites W1978596306 @default.
- W1967005118 cites W1979630887 @default.
- W1967005118 cites W1987064224 @default.
- W1967005118 cites W1990993204 @default.
- W1967005118 cites W1991333931 @default.
- W1967005118 cites W1991421363 @default.
- W1967005118 cites W1994909493 @default.
- W1967005118 cites W1995911285 @default.
- W1967005118 cites W1998154426 @default.
- W1967005118 cites W1999207703 @default.
- W1967005118 cites W2000620255 @default.
- W1967005118 cites W2002190096 @default.
- W1967005118 cites W2003654385 @default.
- W1967005118 cites W2005764402 @default.
- W1967005118 cites W2006699168 @default.
- W1967005118 cites W2007589425 @default.
- W1967005118 cites W2007856011 @default.
- W1967005118 cites W2009085390 @default.
- W1967005118 cites W2009953267 @default.
- W1967005118 cites W2010310827 @default.
- W1967005118 cites W2012537642 @default.
- W1967005118 cites W2012986173 @default.
- W1967005118 cites W2015820342 @default.
- W1967005118 cites W2016732725 @default.
- W1967005118 cites W2023865653 @default.
- W1967005118 cites W2029884547 @default.
- W1967005118 cites W2029930485 @default.
- W1967005118 cites W2035171502 @default.
- W1967005118 cites W2035395679 @default.
- W1967005118 cites W2042797749 @default.
- W1967005118 cites W2048162805 @default.
- W1967005118 cites W2050557699 @default.
- W1967005118 cites W2058061737 @default.
- W1967005118 cites W2063337242 @default.
- W1967005118 cites W2063339794 @default.
- W1967005118 cites W2063919394 @default.
- W1967005118 cites W2064629259 @default.
- W1967005118 cites W2071660897 @default.
- W1967005118 cites W2075881651 @default.
- W1967005118 cites W2077053535 @default.
- W1967005118 cites W2080180950 @default.
- W1967005118 cites W2082061523 @default.
- W1967005118 cites W2082944610 @default.
- W1967005118 cites W2085233756 @default.
- W1967005118 cites W2085758832 @default.
- W1967005118 cites W2088030324 @default.
- W1967005118 cites W2091279754 @default.
- W1967005118 cites W2102773855 @default.
- W1967005118 cites W2106551806 @default.
- W1967005118 cites W2113050239 @default.
- W1967005118 cites W2113973815 @default.
- W1967005118 cites W2114357275 @default.
- W1967005118 cites W2114766453 @default.
- W1967005118 cites W2122877355 @default.
- W1967005118 cites W2123883764 @default.
- W1967005118 cites W2125512488 @default.
- W1967005118 cites W2130676809 @default.
- W1967005118 cites W2134114724 @default.
- W1967005118 cites W2134924469 @default.
- W1967005118 cites W2137007379 @default.
- W1967005118 cites W2139387072 @default.
- W1967005118 cites W2144054698 @default.
- W1967005118 cites W2147059663 @default.
- W1967005118 cites W2147521158 @default.
- W1967005118 cites W2148731561 @default.
- W1967005118 cites W2150800455 @default.
- W1967005118 cites W2151464048 @default.
- W1967005118 cites W2153495666 @default.
- W1967005118 cites W2153586836 @default.
- W1967005118 cites W2155227864 @default.