Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967020111> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1967020111 endingPage "S26" @default.
- W1967020111 startingPage "S26" @default.
- W1967020111 abstract "Dilated cardiomyopathy (DCM) is generally associated with global systolic dysfunction. However, subendocardial ischemia is a relatively common phenomenon and may manifest as metabolically inactive areas of scar, though its exact frequency is unknown. We sought to ascertain the frequency of scar, ischemia and hibernating myocardium in patients with DCM in whom ischemic heart disease was excluded by coronary angiography. Methods: Patients with DCM, ejection fraction <30% and NYHA class III or IV symptoms underwent pharmacological stress (dipyridamole or dobutamine) Rubidium 82 perfusion/Fluorine-18 FDG PET metabolic studies to assess coronary insufficiency and myocardial tissue viability. Patients were excluded if they had significant coronary disease (defined as any lesion >40%, or >60% in a non-dominant right coronary artery) or obstructive valvular disease. Results: Forty-four patients, mean age 56.8±13 (range 20–75) years, 65% male, were studied. Forty (91%) had idiopathic DCM, 15/44 (34%) had atrial fibrillation. Fixed perfusion defects, with decreased FDG uptake, indicating the presence of scar occurred in 40/44 (91%) patients, involving LAD territory in all 40 (100%), RCA territory in 12 (30%) and Cx territory in 9 (23%). Mean scar size was 28±17 (range 3–62)% of total LV mass. Transient defects with pharmacological stress, indicating ischemia, occurred in 7/44 (16%) patients. The territories involved included Cx in 4/7, LAD in 3/7 and RCA in 1/7. Mean ischemic area constituted 14.7±11.6 (range 4–39)% of total LV mass. Conclusions: Although DCM is generally considered a global process, the regional perfusion and metabolic abnormalities on PET scanning in patients with advanced disease described here suggest regional heterogeneity. The observed abnormalities are primarily in LAD territories and fixed, involving almost one third of the myocardium. These data demonstrate the limitation of non-invasive PET to differentiate ischemic and non-ischemic etiology. The septal region appears to be most vulnerable to the perturbations in metabolism that are likely a consequence of increased wall stress. Further study with histologic correlation is required." @default.
- W1967020111 created "2016-06-24" @default.
- W1967020111 creator A5004193656 @default.
- W1967020111 creator A5006688566 @default.
- W1967020111 creator A5015249625 @default.
- W1967020111 creator A5039589228 @default.
- W1967020111 creator A5061706688 @default.
- W1967020111 creator A5068300322 @default.
- W1967020111 creator A5089404827 @default.
- W1967020111 date "2003-10-01" @default.
- W1967020111 modified "2023-10-18" @default.
- W1967020111 title "High prevalence of regional abnormalities in dilated cardiomyopathy" @default.
- W1967020111 doi "https://doi.org/10.1016/s1071-9164(03)00410-x" @default.
- W1967020111 hasPublicationYear "2003" @default.
- W1967020111 type Work @default.
- W1967020111 sameAs 1967020111 @default.
- W1967020111 citedByCount "0" @default.
- W1967020111 crossrefType "journal-article" @default.
- W1967020111 hasAuthorship W1967020111A5004193656 @default.
- W1967020111 hasAuthorship W1967020111A5006688566 @default.
- W1967020111 hasAuthorship W1967020111A5015249625 @default.
- W1967020111 hasAuthorship W1967020111A5039589228 @default.
- W1967020111 hasAuthorship W1967020111A5061706688 @default.
- W1967020111 hasAuthorship W1967020111A5068300322 @default.
- W1967020111 hasAuthorship W1967020111A5089404827 @default.
- W1967020111 hasBestOaLocation W19670201111 @default.
- W1967020111 hasConcept C126322002 @default.
- W1967020111 hasConcept C146957229 @default.
- W1967020111 hasConcept C164705383 @default.
- W1967020111 hasConcept C178853913 @default.
- W1967020111 hasConcept C2776383484 @default.
- W1967020111 hasConcept C2776890861 @default.
- W1967020111 hasConcept C2778198053 @default.
- W1967020111 hasConcept C2778213512 @default.
- W1967020111 hasConcept C2779464278 @default.
- W1967020111 hasConcept C2780062172 @default.
- W1967020111 hasConcept C2781185063 @default.
- W1967020111 hasConcept C500558357 @default.
- W1967020111 hasConcept C541997718 @default.
- W1967020111 hasConcept C71924100 @default.
- W1967020111 hasConcept C78085059 @default.
- W1967020111 hasConceptScore W1967020111C126322002 @default.
- W1967020111 hasConceptScore W1967020111C146957229 @default.
- W1967020111 hasConceptScore W1967020111C164705383 @default.
- W1967020111 hasConceptScore W1967020111C178853913 @default.
- W1967020111 hasConceptScore W1967020111C2776383484 @default.
- W1967020111 hasConceptScore W1967020111C2776890861 @default.
- W1967020111 hasConceptScore W1967020111C2778198053 @default.
- W1967020111 hasConceptScore W1967020111C2778213512 @default.
- W1967020111 hasConceptScore W1967020111C2779464278 @default.
- W1967020111 hasConceptScore W1967020111C2780062172 @default.
- W1967020111 hasConceptScore W1967020111C2781185063 @default.
- W1967020111 hasConceptScore W1967020111C500558357 @default.
- W1967020111 hasConceptScore W1967020111C541997718 @default.
- W1967020111 hasConceptScore W1967020111C71924100 @default.
- W1967020111 hasConceptScore W1967020111C78085059 @default.
- W1967020111 hasIssue "5" @default.
- W1967020111 hasLocation W19670201111 @default.
- W1967020111 hasOpenAccess W1967020111 @default.
- W1967020111 hasPrimaryLocation W19670201111 @default.
- W1967020111 hasRelatedWork W1976224385 @default.
- W1967020111 hasRelatedWork W2014431428 @default.
- W1967020111 hasRelatedWork W2022458368 @default.
- W1967020111 hasRelatedWork W2071201388 @default.
- W1967020111 hasRelatedWork W2082201464 @default.
- W1967020111 hasRelatedWork W2084643349 @default.
- W1967020111 hasRelatedWork W2089346816 @default.
- W1967020111 hasRelatedWork W2317277400 @default.
- W1967020111 hasRelatedWork W2743733577 @default.
- W1967020111 hasRelatedWork W2767339197 @default.
- W1967020111 hasVolume "9" @default.
- W1967020111 isParatext "false" @default.
- W1967020111 isRetracted "false" @default.
- W1967020111 magId "1967020111" @default.
- W1967020111 workType "article" @default.