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- W1967024707 abstract "ACUTE TUBULO-INTERSTTIAL NEPHRITIS IN A PATIENT WITH HEPATITIS B ON TENOFOVIR. Hima Bindu Yalamanchili, Bridgeport Hospital, Bridgeport, Connec cut, USA, Sandeep Ravi, Gilbert W. Moeckel, George Abdelsayed, Irwin Feintzeig. We are repor ng a pa ent who presented with acute renal failure secondary to acute tubulo-inters al nephri s in temporal associa on with tenofovir. 67 year-old African American male with past medical history of chronic ac ve Hepa s B infec on treated with tenofovir and hypertension presented to our hospital with a one week history of nausea, poor appe te, poor oral intake and generalized weakness. His medica ons were atorvasta n, hydrochlorothiazide, and atenolol. There were neither any new medica ons nor any dosage changes prior to current presenta on. Laboratory data disclosed BUN 173mg/dL, serum crea nine 18.6mg/dL (a baseline crea nine 1.23), sodium 126mmol/L, potassium 3.5mmol/L, chloride 82mmol/L, bicarbonate 22mmol/L, calcium 6.6mg/dL, phosphorus 12.5 mg/dL, crea nine phosphokinase of 741 IU/l and the anion gap was 23. Renal ultrasound, complement levels, ANA, ANCA and HIV were normal or nega ve. Urine analysis was nega ve for casts with rare urine eosinophils. Renal biopsy demonstrated acute tubulo-inters al nephri s with focal glomerulosclerosis. His renal func on gradually improved with transient hemo-dialysis (10 days), Tenofovir discon nua on and 3-day course of pulsed methylprednisolone followed by prednisone taper. To our knowledge acute tubulo-inters al nephri s due to tenofovir was not previously described in literature. Few previous case reports of AIN were reported in pa ents with HIV on combina on of tenofovir and atazanavir. Tenofovir alone was associated with Fanconi's syndrome and proximal tubular dysfunc on. With this case report we want to emphasize that acute tubule inters al nephri s should be considered in the differen al diagnosis of renal failure associated with tenofovir and early discon nua on of tenofovir is essen al for recovery of renal func on." @default.
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- W1967024707 date "2011-04-01" @default.
- W1967024707 modified "2023-09-26" @default.
- W1967024707 title "365 Acute Tubulo-Intersttial Nephritis in a Patient With Hepatitis B on Tenofovir" @default.
- W1967024707 doi "https://doi.org/10.1053/j.ajkd.2011.02.368" @default.
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