FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967029440> ?p ?o ?g. }

• W1967029440 endingPage "81" @default.
• W1967029440 startingPage "73" @default.
• W1967029440 abstract "A highly reproducible and robust cell-based high-throughput screening (HTS) assay was adapted for screening of small molecules for antiviral activity against influenza virus strain A/Vietnam/1203/2004 (H5N1). The NIH Molecular Libraries Small Molecule Repository (MLSMR) Molecular Libraries Screening Centers Network (MLSCN) 100,000-compound library was screened at 50 µM. The hit rate (>25% inhibition of the viral cytopathic effect) from the single-dose screen was 0.32%. The hits were evaluated for their antiviral activity, cell toxicity, and selectivity in dose-response experiments. The screen yielded 5 active compounds (SI value >3). One compound showed an SI(50) value of greater than 3, 3 compounds had SI values ranging from greater than 14 to 34, and the most active compound displayed an SI value of 94. The active compounds represent 2 different classes of molecules, benzoquinazolinones and thiazoloimidazoles, which have not been previously identified as having antiviral/anti-influenza activity. These molecules were also effective against influenza A/California/04/2009 virus (H1N1) and other H1N1 and H5N1 virus strains in vitro but not H3N2 strains. Real-time qRT-PCR results reveal that these chemotypes significantly reduced M1 RNA levels as compared to the no-drug influenza-infected Madin Darby canine kidney cells." @default.
• W1967029440 created "2016-06-24" @default.
• W1967029440 creator A5006585063 @default.
• W1967029440 creator A5008171524 @default.
• W1967029440 creator A5015640501 @default.
• W1967029440 creator A5020478086 @default.
• W1967029440 creator A5029409431 @default.
• W1967029440 creator A5033612242 @default.
• W1967029440 creator A5038434103 @default.
• W1967029440 creator A5040087830 @default.
• W1967029440 creator A5041989600 @default.
• W1967029440 creator A5047366671 @default.
• W1967029440 creator A5053966174 @default.
• W1967029440 creator A5074065870 @default.
• W1967029440 creator A5082996108 @default.
• W1967029440 creator A5084535927 @default.
• W1967029440 date "2011-01-01" @default.
• W1967029440 modified "2023-10-15" @default.
• W1967029440 title "Discovery of Novel Benzoquinazolinones and Thiazoloimidazoles, Inhibitors of Influenza H5N1 and H1N1 Viruses, from a Cell-Based High-Throughput Screen" @default.
• W1967029440 cites W1514494431 @default.
• W1967029440 cites W1969288438 @default.
• W1967029440 cites W1971466840 @default.
• W1967029440 cites W1976670588 @default.
• W1967029440 cites W1991001144 @default.
• W1967029440 cites W2011879952 @default.
• W1967029440 cites W2020852349 @default.
• W1967029440 cites W2026106960 @default.
• W1967029440 cites W2036596307 @default.
• W1967029440 cites W2057298557 @default.
• W1967029440 cites W2057700014 @default.
• W1967029440 cites W2070786277 @default.
• W1967029440 cites W2071009174 @default.
• W1967029440 cites W2075704126 @default.
• W1967029440 cites W2084334264 @default.
• W1967029440 cites W2086358466 @default.
• W1967029440 cites W2105466816 @default.
• W1967029440 cites W2114555019 @default.
• W1967029440 cites W2120113718 @default.
• W1967029440 cites W2126047622 @default.
• W1967029440 cites W2131170401 @default.
• W1967029440 cites W2133106116 @default.
• W1967029440 cites W2141991855 @default.
• W1967029440 cites W2146389912 @default.
• W1967029440 cites W2151174475 @default.
• W1967029440 cites W2163960578 @default.
• W1967029440 cites W2166399816 @default.
• W1967029440 cites W2170877664 @default.
• W1967029440 cites W2415264061 @default.
• W1967029440 cites W2429852568 @default.
• W1967029440 doi "https://doi.org/10.1177/1087057110384613" @default.
• W1967029440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21059874" @default.
• W1967029440 hasPublicationYear "2011" @default.
• W1967029440 type Work @default.
• W1967029440 sameAs 1967029440 @default.
• W1967029440 citedByCount "25" @default.
• W1967029440 countsByYear W19670294402012 @default.
• W1967029440 countsByYear W19670294402013 @default.
• W1967029440 countsByYear W19670294402014 @default.
• W1967029440 countsByYear W19670294402015 @default.
• W1967029440 countsByYear W19670294402016 @default.
• W1967029440 countsByYear W19670294402017 @default.
• W1967029440 countsByYear W19670294402018 @default.
• W1967029440 countsByYear W19670294402019 @default.
• W1967029440 countsByYear W19670294402021 @default.
• W1967029440 countsByYear W19670294402023 @default.
• W1967029440 crossrefType "journal-article" @default.
• W1967029440 hasAuthorship W1967029440A5006585063 @default.
• W1967029440 hasAuthorship W1967029440A5008171524 @default.
• W1967029440 hasAuthorship W1967029440A5015640501 @default.
• W1967029440 hasAuthorship W1967029440A5020478086 @default.
• W1967029440 hasAuthorship W1967029440A5029409431 @default.
• W1967029440 hasAuthorship W1967029440A5033612242 @default.
• W1967029440 hasAuthorship W1967029440A5038434103 @default.
• W1967029440 hasAuthorship W1967029440A5040087830 @default.
• W1967029440 hasAuthorship W1967029440A5041989600 @default.
• W1967029440 hasAuthorship W1967029440A5047366671 @default.
• W1967029440 hasAuthorship W1967029440A5053966174 @default.
• W1967029440 hasAuthorship W1967029440A5074065870 @default.
• W1967029440 hasAuthorship W1967029440A5082996108 @default.
• W1967029440 hasAuthorship W1967029440A5084535927 @default.
• W1967029440 hasBestOaLocation W19670294401 @default.
• W1967029440 hasConcept C103697762 @default.
• W1967029440 hasConcept C159047783 @default.
• W1967029440 hasConcept C161624437 @default.
• W1967029440 hasConcept C185592680 @default.
• W1967029440 hasConcept C2522874641 @default.
• W1967029440 hasConcept C2775996393 @default.
• W1967029440 hasConcept C2777546802 @default.
• W1967029440 hasConcept C2779057010 @default.
• W1967029440 hasConcept C2779756493 @default.
• W1967029440 hasConcept C51323132 @default.
• W1967029440 hasConcept C519248777 @default.
• W1967029440 hasConcept C54355233 @default.
• W1967029440 hasConcept C55493867 @default.
• W1967029440 hasConcept C74187038 @default.
• W1967029440 hasConcept C81885089 @default.
• W1967029440 hasConcept C86803240 @default.
• W1967029440 hasConceptScore W1967029440C103697762 @default.

• next