FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967029484> ?p ?o ?g. }

• W1967029484 endingPage "240" @default.
• W1967029484 startingPage "229" @default.
• W1967029484 abstract "An excessive neuronal stimulation through glutamate receptors is known to result in excitotoxic cell death of apoptotic (programmed) character. Granule cells of hippocampal dentate gyrus are believed to be particularly resistant to excitotoxic insults, despite the fact that pyramidal neurons of the hippocampus proper are apparently the most vulnerable brain cells. In this study, we report that neurons derived from the rat 5-day-old dentate gyrus, and maintained in vitro for 6 days, may undergo apoptosis after treatment with L-glutamate, in a dose-dependent manner-with up to 80% of neurons displaying features of programmed cell death after 24 h exposure to 0.5 mM glutamate. This conclusion is based on morphological evaluation of the cultures, nuclear staining with Hoechst 33258 and acridine orange revealing chromatin abnormalities, as well as terminal transferase labeling of DNA fragmentation. Since apoptosis is believed to be an active process involving gene expression, immunocytochemical of c-Fos and c-Jun transcription factor proteins was performed. Elevated expression of both proteins was found to follow quickly (within 1 h) after addition of glutamate. However, this effect was not dose-dependent, thus it does not provide clear correlations to the programmed cell death. In conclusion, this study reports on the establishment of a novel apoptotic model of excitotoxicity, and invites further efforts to investigate a basis for in vitro susceptibility and in vivo resistance of dentate gyrus granule cells to excitotoxic insult evoking apoptosis." @default.
• W1967029484 created "2016-06-24" @default.
• W1967029484 creator A5010975119 @default.
• W1967029484 creator A5060480882 @default.
• W1967029484 date "1997-06-07" @default.
• W1967029484 modified "2023-10-12" @default.
• W1967029484 title "Cellular and molecular correlates of glutamate-evoked neuronal programmed cell death in the in vitro cultures of rat hippocampal dentate gyrus" @default.
• W1967029484 cites W1500101213 @default.
• W1967029484 cites W1589415602 @default.
• W1967029484 cites W1591795694 @default.
• W1967029484 cites W1617042306 @default.
• W1967029484 cites W1957958801 @default.
• W1967029484 cites W1968015127 @default.
• W1967029484 cites W1968488555 @default.
• W1967029484 cites W1969304166 @default.
• W1967029484 cites W1975995347 @default.
• W1967029484 cites W1976385326 @default.
• W1967029484 cites W1977707442 @default.
• W1967029484 cites W1981730865 @default.
• W1967029484 cites W1983931044 @default.
• W1967029484 cites W1995160076 @default.
• W1967029484 cites W1995954315 @default.
• W1967029484 cites W2001335888 @default.
• W1967029484 cites W2016602177 @default.
• W1967029484 cites W2021360899 @default.
• W1967029484 cites W202216076 @default.
• W1967029484 cites W2024499228 @default.
• W1967029484 cites W2042251866 @default.
• W1967029484 cites W2056992784 @default.
• W1967029484 cites W2061650382 @default.
• W1967029484 cites W2066168019 @default.
• W1967029484 cites W2069254216 @default.
• W1967029484 cites W2070964315 @default.
• W1967029484 cites W2074058851 @default.
• W1967029484 cites W2074373265 @default.
• W1967029484 cites W2076485801 @default.
• W1967029484 cites W2077417254 @default.
• W1967029484 cites W2078610607 @default.
• W1967029484 cites W2083255830 @default.
• W1967029484 cites W2083407432 @default.
• W1967029484 cites W2084223366 @default.
• W1967029484 cites W2089408469 @default.
• W1967029484 cites W2092808670 @default.
• W1967029484 cites W2093710529 @default.
• W1967029484 cites W2098553579 @default.
• W1967029484 cites W2138302361 @default.
• W1967029484 cites W2153385508 @default.
• W1967029484 cites W2174668858 @default.
• W1967029484 cites W2259813533 @default.
• W1967029484 cites W232262551 @default.
• W1967029484 cites W2417383855 @default.
• W1967029484 cites W2473472230 @default.
• W1967029484 cites W975418627 @default.
• W1967029484 doi "https://doi.org/10.1016/s0197-0186(96)00152-0" @default.
• W1967029484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9220455" @default.
• W1967029484 hasPublicationYear "1997" @default.
• W1967029484 type Work @default.
• W1967029484 sameAs 1967029484 @default.
• W1967029484 citedByCount "39" @default.
• W1967029484 countsByYear W19670294842012 @default.
• W1967029484 countsByYear W19670294842015 @default.
• W1967029484 countsByYear W19670294842019 @default.
• W1967029484 crossrefType "journal-article" @default.
• W1967029484 hasAuthorship W1967029484A5010975119 @default.
• W1967029484 hasAuthorship W1967029484A5060480882 @default.
• W1967029484 hasConcept C148762608 @default.
• W1967029484 hasConcept C169760540 @default.
• W1967029484 hasConcept C170493617 @default.
• W1967029484 hasConcept C190283241 @default.
• W1967029484 hasConcept C2776464000 @default.
• W1967029484 hasConcept C2778888523 @default.
• W1967029484 hasConcept C2781012912 @default.
• W1967029484 hasConcept C31573885 @default.
• W1967029484 hasConcept C55493867 @default.
• W1967029484 hasConcept C61174792 @default.
• W1967029484 hasConcept C86803240 @default.
• W1967029484 hasConcept C95444343 @default.
• W1967029484 hasConceptScore W1967029484C148762608 @default.
• W1967029484 hasConceptScore W1967029484C169760540 @default.
• W1967029484 hasConceptScore W1967029484C170493617 @default.
• W1967029484 hasConceptScore W1967029484C190283241 @default.
• W1967029484 hasConceptScore W1967029484C2776464000 @default.
• W1967029484 hasConceptScore W1967029484C2778888523 @default.
• W1967029484 hasConceptScore W1967029484C2781012912 @default.
• W1967029484 hasConceptScore W1967029484C31573885 @default.
• W1967029484 hasConceptScore W1967029484C55493867 @default.
• W1967029484 hasConceptScore W1967029484C61174792 @default.
• W1967029484 hasConceptScore W1967029484C86803240 @default.
• W1967029484 hasConceptScore W1967029484C95444343 @default.
• W1967029484 hasIssue "2" @default.
• W1967029484 hasLocation W19670294841 @default.
• W1967029484 hasLocation W19670294842 @default.
• W1967029484 hasOpenAccess W1967029484 @default.
• W1967029484 hasPrimaryLocation W19670294841 @default.
• W1967029484 hasRelatedWork W2012584819 @default.
• W1967029484 hasRelatedWork W2012937732 @default.
• W1967029484 hasRelatedWork W2048616485 @default.
• W1967029484 hasRelatedWork W2072029068 @default.

• next