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- W1967035954 abstract "Antiretrovirals are currently used for the treatment and prevention of HIV infection. However, poor adherence and low tolerability of some existing oral formulations can hinder their efficacy. Long-acting (LA) injectable nanoformulations could help address these complications by simplifying antiretroviral administration. The aim of this study is to inform the optimisation of intramuscular LA formulations for eight antiretrovirals through physiologically based pharmacokinetic (PBPK) modelling.A whole-body PBPK model was constructed using mathematical descriptions of molecular, physiological and anatomical processes defining pharmacokinetics. These models were validated against available clinical data and subsequently used to predict the pharmacokinetics of injectable LA formulationsThe predictions suggest that monthly intramuscular injections are possible for dolutegravir, efavirenz, emtricitabine, raltegravir, rilpivirine and tenofovir provided that technological challenges to control their release rate can be addressed.These data may help inform the target product profiles for LA antiretroviral reformulation strategies." @default.
- W1967035954 created "2016-06-24" @default.
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- W1967035954 date "2014-12-19" @default.
- W1967035954 modified "2023-10-16" @default.
- W1967035954 title "Physiologically Based Pharmacokinetic Modelling to Inform Development of Intramuscular Long-Acting Nanoformulations for HIV" @default.
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- W1967035954 doi "https://doi.org/10.1007/s40262-014-0227-1" @default.
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