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• W1967038923 abstract "Eosinophils play a central role in the pathophysiology of allergic disease. The mechanisms that regulate eosinophil migration are complex; however, chemokines and cytokines produced in both the early and late phases of the asthmatic response appear to cooperate in eosinophil recruitment. In particular, there exists a unique synergy between eotaxin and IL-5. The role of chemokine/cytokine cooperativity has been investigated in the extracellular matrix, adhesion molecule/integrin interactions, receptor polarization and aggregation and the convergence and divergence of intracellular signalling pathways. Understanding the mechanisms whereby eosinophils migrate will allow the development of specific therapeutic strategies aimed at attenuating specific components of the allergic response." @default.
• W1967038923 created "2016-06-24" @default.
• W1967038923 creator A5024433413 @default.
• W1967038923 creator A5043300180 @default.
• W1967038923 date "2000-08-01" @default.
• W1967038923 modified "2023-09-25" @default.
• W1967038923 title "Chemokine and cytokine cooperativity: Eosinophil migration in the asthmatic response" @default.
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• W1967038923 doi "https://doi.org/10.1046/j.1440-1711.2000.00922.x" @default.
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