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- W1967039723 abstract "Interaction of rabbit muscle pyruvate kinase (ATP:pyruvate 2-O-phosphotransferase, EC 2.7.1.40) with inhibitory and activatory effectors was analyzed in terms of the Yagi-Ozawa equation. Straight-line plots obtained for L-phenylalanine + L-alanine and L-phenylalanine + L-phenylalanyl methyl ester (PheAlaOMe) indicated competition for common sites. Parabolic plots for 2-phosphoglycerate and L-phenylalanine or PheAlaOMe suggested lack of competition between these compounds. Biphasic concave plots were obtained for 2-phosphoglycerate and L-1-amino-2-phenylethyl phosphonic acid (PnPhe), and mixtures of inhibitory (L-phenylalanine, PheAlaOMe) and activatory (PnPhe, L-alanine and L-1-aminoethyl phosphonic acid (PnAla)) amino acid derivatives. The latter non-classical Yagi-Ozawa plots can be interpreted in terms of the existence of distinct regulatory sites for inhibitory and activatory ligands." @default.
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- W1967039723 date "1982-04-01" @default.
- W1967039723 modified "2023-10-16" @default.
- W1967039723 title "A kinetic analysis of the distinct regulatory sites on rabbit muscle pyruvate kinase" @default.
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- W1967039723 doi "https://doi.org/10.1016/0167-4838(82)90016-4" @default.
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