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- W1967046925 abstract "The ability of spleen cells from immune defective CBA/N mice to stimulate two types of isogeneic lymphocyte interactions (ILI) was studied. In normal mice adult splenic cells induce proliferation of syngeneic neonatal thymocytes in Type 1 ILI and of syngeneic adult lymph node cells in Type 2 ILI. We have shown that CBA/N spleen cells are inoperative in ILI-Type 1 because the stimulating antigen, murine differentiation antigen 1 (MDA-1), is absent. Murine differentiation antigen 2 (MDA-2), however, is present and Type 2 ILI is evoked by CBA/N spleen cells. The results suggest that MDA-1 and MDA-2 are present on different subsets of B cells. In previous studies in other mice we have shown MDA-1 to be a strong contender for the role of receptor for T-cell signals. Our present findings lend further support to that hypothesis." @default.
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- W1967046925 date "1981-05-01" @default.
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- W1967046925 title "Isogeneic lymphocyte interactions (ILI) in CBA/N mice: Presence of ILI-Type 2 and absence of ILI-Type 1" @default.
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- W1967046925 doi "https://doi.org/10.1016/0008-8749(81)90280-x" @default.
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