Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967060892> ?p ?o ?g. }
- W1967060892 endingPage "131" @default.
- W1967060892 startingPage "125" @default.
- W1967060892 abstract "In this study, indomethacin-loaded thermally oxidized mesoporous silicon microparticles (TOPSi-IMC) were formulated into tablets with excipients in order to improve the dissolution and permeability properties of the poorly soluble drug. Formulations of TOPSi-IMC particles and excipients were prepared at different TOPSi-IMC particle ratios (25, 30 and 35%). The formulations were compressed by direct compression technique with a single punch tablet machine. For comparison, a formulation containing the bulk IMC (indomethacin) and the same excipients without thermally oxidized mesoporous silicon microparticles particles (TOPSi) was prepared and compressed into tablets. The TOPSi-IMC tablets were characterised according to weight, thickness, crushing strength, disintegration time and dissolution rate. The results of this study show that TOPSi-IMC particles can be compressed to a conventional tablet. The release rate of the drug and its permeation across intestinal cells model (Caco-2) from TOPSi-IMC tablets was improved compared to the bulk IMC tablets. The dissolution rate and permeability of IMC from the tablets decreased with increasing ratio of the TOPSi-IMC particles in the formulation. The phenomenon is, presumably, a result of the loss of unique pore structure of the particles due to deformation of the particles under the compression load." @default.
- W1967060892 created "2016-06-24" @default.
- W1967060892 creator A5004833492 @default.
- W1967060892 creator A5008612982 @default.
- W1967060892 creator A5023319173 @default.
- W1967060892 creator A5024426748 @default.
- W1967060892 creator A5030149165 @default.
- W1967060892 creator A5035901179 @default.
- W1967060892 creator A5041763431 @default.
- W1967060892 creator A5056526306 @default.
- W1967060892 creator A5067801086 @default.
- W1967060892 creator A5071356523 @default.
- W1967060892 creator A5075882111 @default.
- W1967060892 creator A5077051012 @default.
- W1967060892 creator A5084003098 @default.
- W1967060892 date "2012-01-01" @default.
- W1967060892 modified "2023-10-16" @default.
- W1967060892 title "Tablet preformulations of indomethacin-loaded mesoporous silicon microparticles" @default.
- W1967060892 cites W1967222288 @default.
- W1967060892 cites W1968828582 @default.
- W1967060892 cites W1975145454 @default.
- W1967060892 cites W1978763817 @default.
- W1967060892 cites W1981953367 @default.
- W1967060892 cites W1988847310 @default.
- W1967060892 cites W1992246868 @default.
- W1967060892 cites W1993102028 @default.
- W1967060892 cites W1994101983 @default.
- W1967060892 cites W2001533174 @default.
- W1967060892 cites W2003633805 @default.
- W1967060892 cites W2005581291 @default.
- W1967060892 cites W2006369950 @default.
- W1967060892 cites W2007790188 @default.
- W1967060892 cites W2011254969 @default.
- W1967060892 cites W2013133034 @default.
- W1967060892 cites W2015559654 @default.
- W1967060892 cites W2017678259 @default.
- W1967060892 cites W2022242346 @default.
- W1967060892 cites W2034515226 @default.
- W1967060892 cites W2034791599 @default.
- W1967060892 cites W2038108827 @default.
- W1967060892 cites W2042090456 @default.
- W1967060892 cites W2042815462 @default.
- W1967060892 cites W2046420363 @default.
- W1967060892 cites W2058586695 @default.
- W1967060892 cites W2067669352 @default.
- W1967060892 cites W2074231342 @default.
- W1967060892 cites W2080859756 @default.
- W1967060892 cites W2080892248 @default.
- W1967060892 cites W2081676858 @default.
- W1967060892 cites W2104619281 @default.
- W1967060892 cites W2105811764 @default.
- W1967060892 cites W2122287862 @default.
- W1967060892 cites W2127791508 @default.
- W1967060892 cites W2152619558 @default.
- W1967060892 cites W2167749477 @default.
- W1967060892 cites W2312199777 @default.
- W1967060892 doi "https://doi.org/10.1016/j.ijpharm.2011.10.040" @default.
- W1967060892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22063301" @default.
- W1967060892 hasPublicationYear "2012" @default.
- W1967060892 type Work @default.
- W1967060892 sameAs 1967060892 @default.
- W1967060892 citedByCount "33" @default.
- W1967060892 countsByYear W19670608922012 @default.
- W1967060892 countsByYear W19670608922013 @default.
- W1967060892 countsByYear W19670608922014 @default.
- W1967060892 countsByYear W19670608922015 @default.
- W1967060892 countsByYear W19670608922016 @default.
- W1967060892 countsByYear W19670608922017 @default.
- W1967060892 countsByYear W19670608922018 @default.
- W1967060892 countsByYear W19670608922019 @default.
- W1967060892 countsByYear W19670608922020 @default.
- W1967060892 countsByYear W19670608922021 @default.
- W1967060892 countsByYear W19670608922023 @default.
- W1967060892 crossrefType "journal-article" @default.
- W1967060892 hasAuthorship W1967060892A5004833492 @default.
- W1967060892 hasAuthorship W1967060892A5008612982 @default.
- W1967060892 hasAuthorship W1967060892A5023319173 @default.
- W1967060892 hasAuthorship W1967060892A5024426748 @default.
- W1967060892 hasAuthorship W1967060892A5030149165 @default.
- W1967060892 hasAuthorship W1967060892A5035901179 @default.
- W1967060892 hasAuthorship W1967060892A5041763431 @default.
- W1967060892 hasAuthorship W1967060892A5056526306 @default.
- W1967060892 hasAuthorship W1967060892A5067801086 @default.
- W1967060892 hasAuthorship W1967060892A5071356523 @default.
- W1967060892 hasAuthorship W1967060892A5075882111 @default.
- W1967060892 hasAuthorship W1967060892A5077051012 @default.
- W1967060892 hasAuthorship W1967060892A5084003098 @default.
- W1967060892 hasConcept C111368507 @default.
- W1967060892 hasConcept C120882062 @default.
- W1967060892 hasConcept C127313418 @default.
- W1967060892 hasConcept C127413603 @default.
- W1967060892 hasConcept C13245373 @default.
- W1967060892 hasConcept C155672457 @default.
- W1967060892 hasConcept C159985019 @default.
- W1967060892 hasConcept C161790260 @default.
- W1967060892 hasConcept C171250308 @default.
- W1967060892 hasConcept C178790620 @default.
- W1967060892 hasConcept C185592680 @default.