FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967066103> ?p ?o ?g. }

• W1967066103 endingPage "188" @default.
• W1967066103 startingPage "178" @default.
• W1967066103 abstract "Abstract Background 99m Tc labeled radiotracers used in clinical practice lack the perfect characteristics for myocardial perfusion imaging. In particular, the high liver uptake can interfere in the interpretation of the inferior myocardial wall. Within the tricarbonyl approach, we used tris(pyrazolyl)methane 99m Tc organometallic complexes as a lead structure. Herein we present the production, in vivo and in vitro metabolic studies in rats and the first in vivo biodistribution in rats for tri‐methoxy‐tris‐pyrazolyl‐ 99m Tc‐(CO) 3 ( 99m Tc‐TMEOP), compared with 99m Tc‐sestamibi and 99m Tc‐tetrofosmin. Methods The chemical identity of 99m Tc‐TMEOP was characterized by RP‐HPLC. The octanol–water partition coefficient was determined under physiological conditions. In vitro stability and protein binding were determined using RP‐HPLC. In vivo stability was determined in blood, heart, liver and kidney homogenates, intestine and urine using RP‐HPLC. In vivo biodistribution was determined using dynamic planar acquisitions. Pinhole gated SPECT images were performed in other animals. Cardiac, liver and lung uptake were expressed as differential uptake ratios by drawing regions of interest in the organs of interest and around the total body. Heart–liver and heart–lung ratios were derived. Cardiac uptake was also expressed as percentage of injected activity. SPECT images were processed to determine the heart–liver ratio on SPECT images, to compare functional parameters between different tracers and to visualize homogeneous intracardiac tracer distribution. Results 99m Tc‐TMEOP is a moderately lipophilic cation, is stable and does not undergo any transformation in vitro . 99m Tc‐TMEOP also shows a high in vivo stability. In vivo imaging shows liver kinetics faster than those of 99m Tc‐sestamibi and 99m Tc‐tetrofosmin. Cardiac uptake and functional analysis of pinhole gated SPECT data are comparable to those of 99m Tc‐sestamibi and 99m Tc‐tetrofosmin. Conclusion Although 99m Tc‐TMEOP shows a cardiac uptake between those of 99m Tc‐sestamibi and 99m Tc‐tetrofosmin, a better heart–liver ratio is obtained due to the faster liver washout. These results suggest possible faster cardiac perfusion imaging using 99m Tc‐TMEOP without liver activity interference. Copyright © 2010 John Wiley & Sons, Ltd." @default.
• W1967066103 created "2016-06-24" @default.
• W1967066103 creator A5014997038 @default.
• W1967066103 creator A5030965445 @default.
• W1967066103 creator A5035336981 @default.
• W1967066103 creator A5076475427 @default.
• W1967066103 creator A5079580640 @default.
• W1967066103 creator A5085397508 @default.
• W1967066103 creator A5086947067 @default.
• W1967066103 creator A5088835551 @default.
• W1967066103 date "2010-12-29" @default.
• W1967066103 modified "2023-10-11" @default.
• W1967066103 title "Rapid hepatic clearance of 99mTc-TMEOP: a new candidate for myocardial perfusion imaging" @default.
• W1967066103 cites W1966718543 @default.
• W1967066103 cites W1967411424 @default.
• W1967066103 cites W1970812458 @default.
• W1967066103 cites W1970991888 @default.
• W1967066103 cites W1979151671 @default.
• W1967066103 cites W1985735985 @default.
• W1967066103 cites W1988033181 @default.
• W1967066103 cites W1992232863 @default.
• W1967066103 cites W1996683540 @default.
• W1967066103 cites W1997333735 @default.
• W1967066103 cites W1999065263 @default.
• W1967066103 cites W2007152889 @default.
• W1967066103 cites W2013082137 @default.
• W1967066103 cites W2014375044 @default.
• W1967066103 cites W2017745269 @default.
• W1967066103 cites W2028939834 @default.
• W1967066103 cites W2056798637 @default.
• W1967066103 cites W2059011987 @default.
• W1967066103 cites W2063910856 @default.
• W1967066103 cites W2064992833 @default.
• W1967066103 cites W2069028617 @default.
• W1967066103 cites W2071611167 @default.
• W1967066103 cites W2079144973 @default.
• W1967066103 cites W2083793124 @default.
• W1967066103 cites W2088435926 @default.
• W1967066103 cites W2091598178 @default.
• W1967066103 cites W2111501638 @default.
• W1967066103 cites W2115798877 @default.
• W1967066103 cites W2146493245 @default.
• W1967066103 cites W2151013564 @default.
• W1967066103 doi "https://doi.org/10.1002/cmmi.413" @default.
• W1967066103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21861278" @default.
• W1967066103 hasPublicationYear "2010" @default.
• W1967066103 type Work @default.
• W1967066103 sameAs 1967066103 @default.
• W1967066103 citedByCount "10" @default.
• W1967066103 countsByYear W19670661032013 @default.
• W1967066103 countsByYear W19670661032014 @default.
• W1967066103 countsByYear W19670661032017 @default.
• W1967066103 countsByYear W19670661032018 @default.
• W1967066103 countsByYear W19670661032020 @default.
• W1967066103 crossrefType "journal-article" @default.
• W1967066103 hasAuthorship W1967066103A5014997038 @default.
• W1967066103 hasAuthorship W1967066103A5030965445 @default.
• W1967066103 hasAuthorship W1967066103A5035336981 @default.
• W1967066103 hasAuthorship W1967066103A5076475427 @default.
• W1967066103 hasAuthorship W1967066103A5079580640 @default.
• W1967066103 hasAuthorship W1967066103A5085397508 @default.
• W1967066103 hasAuthorship W1967066103A5086947067 @default.
• W1967066103 hasAuthorship W1967066103A5088835551 @default.
• W1967066103 hasConcept C126322002 @default.
• W1967066103 hasConcept C146957229 @default.
• W1967066103 hasConcept C150903083 @default.
• W1967066103 hasConcept C179998833 @default.
• W1967066103 hasConcept C185592680 @default.
• W1967066103 hasConcept C202751555 @default.
• W1967066103 hasConcept C207001950 @default.
• W1967066103 hasConcept C2777807558 @default.
• W1967066103 hasConcept C2780091579 @default.
• W1967066103 hasConcept C2989005 @default.
• W1967066103 hasConcept C43617362 @default.
• W1967066103 hasConcept C55493867 @default.
• W1967066103 hasConcept C71924100 @default.
• W1967066103 hasConcept C86803240 @default.
• W1967066103 hasConceptScore W1967066103C126322002 @default.
• W1967066103 hasConceptScore W1967066103C146957229 @default.
• W1967066103 hasConceptScore W1967066103C150903083 @default.
• W1967066103 hasConceptScore W1967066103C179998833 @default.
• W1967066103 hasConceptScore W1967066103C185592680 @default.
• W1967066103 hasConceptScore W1967066103C202751555 @default.
• W1967066103 hasConceptScore W1967066103C207001950 @default.
• W1967066103 hasConceptScore W1967066103C2777807558 @default.
• W1967066103 hasConceptScore W1967066103C2780091579 @default.
• W1967066103 hasConceptScore W1967066103C2989005 @default.
• W1967066103 hasConceptScore W1967066103C43617362 @default.
• W1967066103 hasConceptScore W1967066103C55493867 @default.
• W1967066103 hasConceptScore W1967066103C71924100 @default.
• W1967066103 hasConceptScore W1967066103C86803240 @default.
• W1967066103 hasIssue "4" @default.
• W1967066103 hasLocation W19670661031 @default.
• W1967066103 hasLocation W19670661032 @default.
• W1967066103 hasOpenAccess W1967066103 @default.
• W1967066103 hasPrimaryLocation W19670661031 @default.
• W1967066103 hasRelatedWork W1952051237 @default.
• W1967066103 hasRelatedWork W1969303838 @default.

• next