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• W1967067220 abstract "Trefoil factor 3 (TFF3) is a member of the TFF-domain peptide family and essential in regulating cell migration and maintaining mucosal integrity in gastrointestinal tract. However, the role of TFF3 and its downstream regulating mechanisms in cancer cell migration remain unclear. We previously reported that TFF3 prolonged the up-regulation of Twist protein to modulate IL-8 secretion in intestinal epithelial cells. In this study, we investigated the role of Twist protein in TFF3-induced migration of SGC7901 cells. While Twist was activated by TFF3, siRNA-mediated knockdown of Twist abolished TFF3-induced cell migration. Furthermore, the migration related marker CK-8 as well as ZO-1 and MMP-9 was also regulated by TFF3 via a Twist-dependent mechanism. Our study suggests that Twist, as an important potential downstream effector, plays a key role in TFF3-modulated metastasis in gastric cancer and can be a promising therapeutic target against intestinal-type gastric cancer." @default.
• W1967067220 created "2016-06-24" @default.
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• W1967067220 date "2013-08-01" @default.
• W1967067220 modified "2023-09-25" @default.
• W1967067220 title "Trefoil factor 3 peptide regulates migration via a Twist-dependent pathway in gastric cell" @default.
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• W1967067220 doi "https://doi.org/10.1016/j.bbrc.2013.06.115" @default.
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