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• W1967099579 abstract "Synthetic molecule microarrays, consisting of many different compounds spotted onto a planar surface such as modified glass or cellulose, have proven to be useful tools for the multiplexed analysis of small molecule– and peptide–protein interactions. However, these arrays are technically difficult to manufacture and use with high reproducibility and require specialized equipment. Here we report a more convenient alternative composed of color-encoded beads that display a small molecule protein ligand on the surface. Quantitative, multiplexed assay of protein binding to up to 24 different ligands can be achieved using a common flow cytometer for the readout. This technology should be useful for evaluating hits from library screening efforts, the determination of structure activity relationships, and certain types of serological analyses." @default.
• W1967099579 created "2016-06-24" @default.
• W1967099579 creator A5012303330 @default.
• W1967099579 creator A5081080450 @default.
• W1967099579 date "2013-11-20" @default.
• W1967099579 modified "2023-10-16" @default.
• W1967099579 title "A Liquid Array Platform for the Multiplexed Analysis of Synthetic Molecule–Protein Interactions" @default.
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• W1967099579 doi "https://doi.org/10.1021/cb400806r" @default.
• W1967099579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3944025" @default.
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• W1967099579 hasPublicationYear "2013" @default.
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