FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967104908> ?p ?o ?g. }

• W1967104908 endingPage "2107" @default.
• W1967104908 startingPage "2101" @default.
• W1967104908 abstract "Metallothionein (MT), a low molecular mass, cysteine-rich protein, is a model system for metal ion-directed folding due to its diverse metal binding properties. In this minireview, the current status of theoretical and experimental studies that have focused primarily on the initial metallation steps involving the metal-free, or apo, MT and divalent metals, Zn(2+) and Cd(2+) is described. Apo-MT has recently been reported to be present in the cell in quantities equal to that of the metallated protein, which might indicate a potential role for the protein in the absence of metals. Molecular mechanics-molecular dynamics (MM3/MD) calculations carried out on the demetallation of cadmium-coordinated MT isoform 1a indicate structural stability of the metal-free protein with significant retention of the backbone conformation imposed by the metal-thiolate clusters present in the metallated holo-protein. Significantly, the cysteinyl sulfurs were found inverted to the outside of a quite compact sphere. In contrast, MM3/MD calculations of apo-MT starting from a linear strand did not possess any structural stability and can be described as a random coil conformation. Evidence for the sequence of metallation is discussed, together with current experimental data to support either a cooperative or sequential binding mechanisms." @default.
• W1967104908 created "2016-06-24" @default.
• W1967104908 creator A5009769045 @default.
• W1967104908 creator A5023042480 @default.
• W1967104908 date "2006-12-01" @default.
• W1967104908 modified "2023-10-13" @default.
• W1967104908 title "Metal-dependent protein folding: Metallation of metallothionein" @default.
• W1967104908 cites W1493451689 @default.
• W1967104908 cites W149747430 @default.
• W1967104908 cites W1507555586 @default.
• W1967104908 cites W1507671215 @default.
• W1967104908 cites W1512639331 @default.
• W1967104908 cites W1598149828 @default.
• W1967104908 cites W1600978980 @default.
• W1967104908 cites W1615397418 @default.
• W1967104908 cites W1976955665 @default.
• W1967104908 cites W1978842370 @default.
• W1967104908 cites W1994309915 @default.
• W1967104908 cites W2000615013 @default.
• W1967104908 cites W2003488256 @default.
• W1967104908 cites W2005484513 @default.
• W1967104908 cites W2021648695 @default.
• W1967104908 cites W2034249506 @default.
• W1967104908 cites W2052375477 @default.
• W1967104908 cites W2057348161 @default.
• W1967104908 cites W2057551117 @default.
• W1967104908 cites W2059165673 @default.
• W1967104908 cites W2067943687 @default.
• W1967104908 cites W2070009684 @default.
• W1967104908 cites W2088395378 @default.
• W1967104908 cites W2105184212 @default.
• W1967104908 cites W2145402257 @default.
• W1967104908 cites W2153061416 @default.
• W1967104908 cites W2333157284 @default.
• W1967104908 cites W2404096635 @default.
• W1967104908 cites W595103364 @default.
• W1967104908 cites W6354852 @default.
• W1967104908 doi "https://doi.org/10.1016/j.jinorgbio.2006.09.005" @default.
• W1967104908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17055583" @default.
• W1967104908 hasPublicationYear "2006" @default.
• W1967104908 type Work @default.
• W1967104908 sameAs 1967104908 @default.
• W1967104908 citedByCount "83" @default.
• W1967104908 countsByYear W19671049082012 @default.
• W1967104908 countsByYear W19671049082013 @default.
• W1967104908 countsByYear W19671049082014 @default.
• W1967104908 countsByYear W19671049082015 @default.
• W1967104908 countsByYear W19671049082016 @default.
• W1967104908 countsByYear W19671049082017 @default.
• W1967104908 countsByYear W19671049082018 @default.
• W1967104908 countsByYear W19671049082019 @default.
• W1967104908 countsByYear W19671049082020 @default.
• W1967104908 countsByYear W19671049082021 @default.
• W1967104908 countsByYear W19671049082023 @default.
• W1967104908 crossrefType "journal-article" @default.
• W1967104908 hasAuthorship W1967104908A5009769045 @default.
• W1967104908 hasAuthorship W1967104908A5023042480 @default.
• W1967104908 hasConcept C119599485 @default.
• W1967104908 hasConcept C12554922 @default.
• W1967104908 hasConcept C127413603 @default.
• W1967104908 hasConcept C133571119 @default.
• W1967104908 hasConcept C147597530 @default.
• W1967104908 hasConcept C17165728 @default.
• W1967104908 hasConcept C178790620 @default.
• W1967104908 hasConcept C181199279 @default.
• W1967104908 hasConcept C185592680 @default.
• W1967104908 hasConcept C204328495 @default.
• W1967104908 hasConcept C20719415 @default.
• W1967104908 hasConcept C2776545253 @default.
• W1967104908 hasConcept C2779201268 @default.
• W1967104908 hasConcept C34349673 @default.
• W1967104908 hasConcept C544153396 @default.
• W1967104908 hasConcept C544657597 @default.
• W1967104908 hasConcept C55493867 @default.
• W1967104908 hasConcept C59593255 @default.
• W1967104908 hasConcept C71240020 @default.
• W1967104908 hasConcept C8010536 @default.
• W1967104908 hasConcept C86803240 @default.
• W1967104908 hasConceptScore W1967104908C119599485 @default.
• W1967104908 hasConceptScore W1967104908C12554922 @default.
• W1967104908 hasConceptScore W1967104908C127413603 @default.
• W1967104908 hasConceptScore W1967104908C133571119 @default.
• W1967104908 hasConceptScore W1967104908C147597530 @default.
• W1967104908 hasConceptScore W1967104908C17165728 @default.
• W1967104908 hasConceptScore W1967104908C178790620 @default.
• W1967104908 hasConceptScore W1967104908C181199279 @default.
• W1967104908 hasConceptScore W1967104908C185592680 @default.
• W1967104908 hasConceptScore W1967104908C204328495 @default.
• W1967104908 hasConceptScore W1967104908C20719415 @default.
• W1967104908 hasConceptScore W1967104908C2776545253 @default.
• W1967104908 hasConceptScore W1967104908C2779201268 @default.
• W1967104908 hasConceptScore W1967104908C34349673 @default.
• W1967104908 hasConceptScore W1967104908C544153396 @default.
• W1967104908 hasConceptScore W1967104908C544657597 @default.
• W1967104908 hasConceptScore W1967104908C55493867 @default.
• W1967104908 hasConceptScore W1967104908C59593255 @default.
• W1967104908 hasConceptScore W1967104908C71240020 @default.
• W1967104908 hasConceptScore W1967104908C8010536 @default.

• next