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- W1967111676 abstract "Reports have appeared on large molecular weight RNAs associated with the mitochondria of higher organisms. These include HeLa cells [ 1 ] , BHK-2 1 cells [2] , mouse L-cells [3,4] , rat liver [4, S] and Xenopus ovary [6] . This RNA consists of two predominant species found to be 17 S and 13 S by sedimentation [2, 31 . Values determined by electrophoresis for the larger species vary between 21 S-17 S and for the smaller species 13 S-12 S [ 1,4-61. Mitochondria of Xenopus ovary contain a 60 S RNP particle which was capable of using polyuridylic acid as an m-RNA [6] and from which was isolated 21 S and 13 S RNA. In BHK cells, the 17 S and 13 S RNAs were shown to be associated with separate RNP particles [7] (presumed to be ribosomal subunits) but in the other reports no function was assigned to the RNAs. We report here the existence, in chick liver, of an RNP particle which sediments in sucrose gradients at 55 S. This particle is shown to be involved in mitochondrial protein synthesis and it can be regarded as the mitochondrial ribosome. Further, these ribosomes contain ‘18 S’ and ‘12 S’ RNA which are shown to be mitochondrial-gene products." @default.
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- W1967111676 date "1971-05-10" @default.
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- W1967111676 title "The mitochondrial ribosome and ribosomal RNA of the chick" @default.
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- W1967111676 doi "https://doi.org/10.1016/0014-5793(71)80620-8" @default.
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