FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967127282> ?p ?o ?g. }

• W1967127282 endingPage "1156" @default.
• W1967127282 startingPage "1151" @default.
• W1967127282 abstract "Telomere shortening has been reported in several diseases including atherosclerosis and Type 1 diabetes. Asian Indians have an increased predilection for Type 2 diabetes and premature coronary artery disease. The aim of this study was to determine whether telomeric shortening occurs in Asian Indian Type 2 diabetic patients.Using Southern-blot analysis we determined mean terminal restriction fragment (TRF) length, a measure of average telomere size, in leucocyte DNA. Type 2 diabetic patients without any diabetes-related complications (n = 40) and age- and sex-matched control non-diabetic subjects (n = 40) were selected from the Chennai Urban Rural Epidemiology Study (CURES). Plasma level of malondialdehyde (MDA), a marker of lipid peroxidation, was measured by TBARS (thiobarbituric acid reactive substances) using a fluorescence method.Mean (+/- SE) TRF lengths of the Type 2 diabetic patients (6.01 +/- 0.2 kb) were significantly shorter than those of the control subjects (9.11 +/- 0.6 kb) (P = 0.0001). Among the biochemical parameters, only levels of TBARS showed a negative correlation with shortened telomeres in the diabetic subjects (r = -0.36; P = 0.02). However, telomere lengths were negatively correlated with insulin resistance (HOMA-IR) (r = -0.4; P = 0.01) and age (r = -0.3; P = 0.058) and positively correlated with HDL levels (r = 0.4; P = 0.01) in the control subjects. Multiple linear regression (MLR) analysis revealed diabetes to be significantly (P < 0.0001) associated with shortening of TRF lengths.Telomere shortening occurs in Asian Indian Type 2 diabetic patients." @default.
• W1967127282 created "2016-06-24" @default.
• W1967127282 creator A5034363861 @default.
• W1967127282 creator A5075723592 @default.
• W1967127282 creator A5087023083 @default.
• W1967127282 date "2005-08-15" @default.
• W1967127282 modified "2023-10-10" @default.
• W1967127282 title "Telomere shortening occurs in Asian Indian Type 2 diabetic patients" @default.
• W1967127282 cites W106107227 @default.
• W1967127282 cites W1497143641 @default.
• W1967127282 cites W1971361148 @default.
• W1967127282 cites W1973034871 @default.
• W1967127282 cites W1974739160 @default.
• W1967127282 cites W1981132305 @default.
• W1967127282 cites W1983673827 @default.
• W1967127282 cites W1989289507 @default.
• W1967127282 cites W1989713074 @default.
• W1967127282 cites W1990423201 @default.
• W1967127282 cites W1995602755 @default.
• W1967127282 cites W1999872096 @default.
• W1967127282 cites W2020267609 @default.
• W1967127282 cites W2025351604 @default.
• W1967127282 cites W2027598856 @default.
• W1967127282 cites W2027957140 @default.
• W1967127282 cites W2028879048 @default.
• W1967127282 cites W2039878231 @default.
• W1967127282 cites W2043191076 @default.
• W1967127282 cites W2046293159 @default.
• W1967127282 cites W2054684152 @default.
• W1967127282 cites W2064344250 @default.
• W1967127282 cites W2067320344 @default.
• W1967127282 cites W2068853013 @default.
• W1967127282 cites W2071444458 @default.
• W1967127282 cites W2071673220 @default.
• W1967127282 cites W2079993653 @default.
• W1967127282 cites W2081327669 @default.
• W1967127282 cites W2086098982 @default.
• W1967127282 cites W2094916776 @default.
• W1967127282 cites W2101861123 @default.
• W1967127282 cites W2120926079 @default.
• W1967127282 cites W2127657628 @default.
• W1967127282 cites W2128014750 @default.
• W1967127282 cites W2131954065 @default.
• W1967127282 cites W2149634356 @default.
• W1967127282 cites W2152288884 @default.
• W1967127282 cites W2158245724 @default.
• W1967127282 cites W2160234571 @default.
• W1967127282 cites W2162668251 @default.
• W1967127282 cites W2165792590 @default.
• W1967127282 cites W2168160317 @default.
• W1967127282 doi "https://doi.org/10.1111/j.1464-5491.2005.01574.x" @default.
• W1967127282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16108841" @default.
• W1967127282 hasPublicationYear "2005" @default.
• W1967127282 type Work @default.
• W1967127282 sameAs 1967127282 @default.
• W1967127282 citedByCount "159" @default.
• W1967127282 countsByYear W19671272822012 @default.
• W1967127282 countsByYear W19671272822013 @default.
• W1967127282 countsByYear W19671272822014 @default.
• W1967127282 countsByYear W19671272822015 @default.
• W1967127282 countsByYear W19671272822016 @default.
• W1967127282 countsByYear W19671272822017 @default.
• W1967127282 countsByYear W19671272822018 @default.
• W1967127282 countsByYear W19671272822019 @default.
• W1967127282 countsByYear W19671272822020 @default.
• W1967127282 countsByYear W19671272822021 @default.
• W1967127282 countsByYear W19671272822022 @default.
• W1967127282 countsByYear W19671272822023 @default.
• W1967127282 crossrefType "journal-article" @default.
• W1967127282 hasAuthorship W1967127282A5034363861 @default.
• W1967127282 hasAuthorship W1967127282A5075723592 @default.
• W1967127282 hasAuthorship W1967127282A5087023083 @default.
• W1967127282 hasBestOaLocation W19671272822 @default.
• W1967127282 hasConcept C104317684 @default.
• W1967127282 hasConcept C126322002 @default.
• W1967127282 hasConcept C134018914 @default.
• W1967127282 hasConcept C177336024 @default.
• W1967127282 hasConcept C2776151105 @default.
• W1967127282 hasConcept C2777180221 @default.
• W1967127282 hasConcept C2777352226 @default.
• W1967127282 hasConcept C2777504301 @default.
• W1967127282 hasConcept C2778401633 @default.
• W1967127282 hasConcept C2780829032 @default.
• W1967127282 hasConcept C2910068830 @default.
• W1967127282 hasConcept C54355233 @default.
• W1967127282 hasConcept C555293320 @default.
• W1967127282 hasConcept C71924100 @default.
• W1967127282 hasConcept C86803240 @default.
• W1967127282 hasConceptScore W1967127282C104317684 @default.
• W1967127282 hasConceptScore W1967127282C126322002 @default.
• W1967127282 hasConceptScore W1967127282C134018914 @default.
• W1967127282 hasConceptScore W1967127282C177336024 @default.
• W1967127282 hasConceptScore W1967127282C2776151105 @default.
• W1967127282 hasConceptScore W1967127282C2777180221 @default.
• W1967127282 hasConceptScore W1967127282C2777352226 @default.
• W1967127282 hasConceptScore W1967127282C2777504301 @default.
• W1967127282 hasConceptScore W1967127282C2778401633 @default.
• W1967127282 hasConceptScore W1967127282C2780829032 @default.

• next