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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967127777> ?p ?o ?g. }

• W1967127777 endingPage "19871" @default.
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• W1967127777 abstract "We report that the overexpression of mitochondrial ribosomal protein MRPS18-2 (S18-2) can immortalize primary rat embryonic fibroblasts (REFs). The immortalized cells (18IM) lose contact inhibition, form foci, and are capable of anchorage-independent growth. Concurrently, mesodermal markers, such as vimentin, smooth muscle actin, and Fut4, disappear completely. 18IM cells express embryonic stem cell markers, such as SSEA-1, Sox2, and Oct3/4. In confluent cultures, a portion of cells also express ectoderm- and endoderm-specific pan-keratin, ectoderm-specific beta-III-tubulin, mesoderm-specific MHC class II, and become stainable for fat with Oil red O. None of these changes was detected in c-myc+Ha-ras (MR)-transformed cells. In immunodeficient mice, 18IM cells formed small transiently growing tumors that have down-regulated SSEA-1 and showed pan-keratin staining. We conclude that S18-2 can immortalize REFs and induces them to express stem cell traits." @default.
• W1967127777 created "2016-06-24" @default.
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• W1967127777 date "2009-11-24" @default.
• W1967127777 modified "2023-10-01" @default.
• W1967127777 title "MRPS18–2 protein immortalizes primary rat embryonic fibroblasts and endows them with stem cell-like properties" @default.
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• W1967127777 doi "https://doi.org/10.1073/pnas.0911545106" @default.
• W1967127777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2785258" @default.
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