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• W1967135832 abstract "Aberrant expression of embryonic epithelial-mesenchymal transition-inducing transcription factors (EMT-TFs) in epithelial cells triggers EMT, neoplastic transformation, stemness, and metastatic dissemination. We found that regulation and functions of EMT-TFs are different in malignant melanoma. SNAIL2 and ZEB2 transcription factors are expressed in normal melanocytes and behave as tumor-suppressor proteins by activating an MITF-dependent melanocyte differentiation program. In response to NRAS/BRAF activation, EMT-TF network undergoes a profound reorganization in favor of TWIST1 and ZEB1. This reversible switch cooperates with BRAF in promoting dedifferentiation and neoplastic transformation of melanocytes. We detected EMT-TF reprogramming in late-stage melanoma in association with enhanced phospho-ERK levels. This switch results in E-cadherin loss, enhanced invasion, and constitutes an independent factor of poor prognosis in melanoma patients." @default.
• W1967135832 created "2016-06-24" @default.
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• W1967135832 date "2013-10-01" @default.
• W1967135832 modified "2023-10-14" @default.
• W1967135832 title "A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma" @default.
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• W1967135832 doi "https://doi.org/10.1016/j.ccr.2013.08.018" @default.
• W1967135832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24075834" @default.
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