FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967138211> ?p ?o ?g. }

• W1967138211 endingPage "910" @default.
• W1967138211 startingPage "902" @default.
• W1967138211 abstract "Effects of the opioid receptor like-1 (ORL-1) receptor agonist Ro 64-6198 (0.1, 0.3, and 1.0 mg/kg intraperitoneally (i.p.)) on operant ethanol self-administration and activation of self-administration by ethanol deprivation were studied in male Wistar rats. Acute administration of Ro 64-6198 caused a dose-dependent reduction of ethanol self-administration. In comparison, the opioid antagonist naltrexone (0.1, 0.3, and 1.0 mg/kg i.p.) inhibited ethanol self-administration at all doses tested. Ethanol deprivation for 10 days significantly increased ethanol self-administration during the first 2 days after deprivation. Daily pretreatment with Ro 64-6198 (0.3 mg/kg) or naltrexone (0.3 mg/kg) during the last 3 days of ethanol deprivation abolished the deprivation-induced increase in ethanol intake. Thus, stimulation of the ORL-1 receptors by Ro 64-6198 reduced the acute reinforcing effects of ethanol and prevented relapse-like behavior in the ethanol-deprivation model in a similar manner as a blockade of opioid receptors by naltrexone. Ro 64-6198 at 0.1 and 0.3 mg/kg doses did not alter self-administration of 0.2% saccharin solution, indicating an apparent selectivity of this compound in modification of ethanol reward. These findings add further support to the idea that Ro 64-6198 and potentially other synthetic ORL-1 receptor agonists are as effective as naltrexone in blocking the actions of ethanol important for its addictive potential in animal experiments, and therefore may have therapeutic value in the treatment of alcoholism." @default.
• W1967138211 created "2016-06-24" @default.
• W1967138211 creator A5005988182 @default.
• W1967138211 creator A5039487284 @default.
• W1967138211 creator A5058999301 @default.
• W1967138211 creator A5075051916 @default.
• W1967138211 date "2006-07-26" @default.
• W1967138211 modified "2023-10-01" @default.
• W1967138211 title "The Nociceptin/Orphanin FQ Receptor Agonist Ro 64-6198 Reduces Alcohol Self-Administration and Prevents Relapse-Like Alcohol Drinking" @default.
• W1967138211 cites W1970873299 @default.
• W1967138211 cites W1971237060 @default.
• W1967138211 cites W1977436056 @default.
• W1967138211 cites W1979495245 @default.
• W1967138211 cites W1980637329 @default.
• W1967138211 cites W1981048284 @default.
• W1967138211 cites W1983361531 @default.
• W1967138211 cites W1995713912 @default.
• W1967138211 cites W1996448217 @default.
• W1967138211 cites W1996561349 @default.
• W1967138211 cites W2007928872 @default.
• W1967138211 cites W2008622358 @default.
• W1967138211 cites W2014237020 @default.
• W1967138211 cites W2016054341 @default.
• W1967138211 cites W2020262342 @default.
• W1967138211 cites W2020496703 @default.
• W1967138211 cites W2021136584 @default.
• W1967138211 cites W2031170958 @default.
• W1967138211 cites W2032084685 @default.
• W1967138211 cites W2034128256 @default.
• W1967138211 cites W2035213255 @default.
• W1967138211 cites W2044708568 @default.
• W1967138211 cites W2048466053 @default.
• W1967138211 cites W2051455839 @default.
• W1967138211 cites W2054303162 @default.
• W1967138211 cites W2055818086 @default.
• W1967138211 cites W2055873049 @default.
• W1967138211 cites W2060588252 @default.
• W1967138211 cites W2064420586 @default.
• W1967138211 cites W2066082102 @default.
• W1967138211 cites W2066335559 @default.
• W1967138211 cites W2073846167 @default.
• W1967138211 cites W2080181711 @default.
• W1967138211 cites W2080862729 @default.
• W1967138211 cites W2082307932 @default.
• W1967138211 cites W2087331621 @default.
• W1967138211 cites W2089464278 @default.
• W1967138211 cites W2093559862 @default.
• W1967138211 cites W2104538950 @default.
• W1967138211 cites W2121603624 @default.
• W1967138211 cites W2130325363 @default.
• W1967138211 cites W2139060090 @default.
• W1967138211 cites W2180074457 @default.
• W1967138211 doi "https://doi.org/10.1038/sj.npp.1301169" @default.
• W1967138211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16880770" @default.
• W1967138211 hasPublicationYear "2006" @default.
• W1967138211 type Work @default.
• W1967138211 sameAs 1967138211 @default.
• W1967138211 citedByCount "82" @default.
• W1967138211 countsByYear W19671382112012 @default.
• W1967138211 countsByYear W19671382112013 @default.
• W1967138211 countsByYear W19671382112014 @default.
• W1967138211 countsByYear W19671382112015 @default.
• W1967138211 countsByYear W19671382112016 @default.
• W1967138211 countsByYear W19671382112017 @default.
• W1967138211 countsByYear W19671382112018 @default.
• W1967138211 countsByYear W19671382112019 @default.
• W1967138211 countsByYear W19671382112020 @default.
• W1967138211 countsByYear W19671382112021 @default.
• W1967138211 countsByYear W19671382112023 @default.
• W1967138211 crossrefType "journal-article" @default.
• W1967138211 hasAuthorship W1967138211A5005988182 @default.
• W1967138211 hasAuthorship W1967138211A5039487284 @default.
• W1967138211 hasAuthorship W1967138211A5058999301 @default.
• W1967138211 hasAuthorship W1967138211A5075051916 @default.
• W1967138211 hasBestOaLocation W19671382111 @default.
• W1967138211 hasConcept C125439840 @default.
• W1967138211 hasConcept C126322002 @default.
• W1967138211 hasConcept C134018914 @default.
• W1967138211 hasConcept C170493617 @default.
• W1967138211 hasConcept C185592680 @default.
• W1967138211 hasConcept C2777972943 @default.
• W1967138211 hasConcept C2778555786 @default.
• W1967138211 hasConcept C2778938600 @default.
• W1967138211 hasConcept C2779886867 @default.
• W1967138211 hasConcept C2780161600 @default.
• W1967138211 hasConcept C2781063702 @default.
• W1967138211 hasConcept C55493867 @default.
• W1967138211 hasConcept C71924100 @default.
• W1967138211 hasConcept C88016717 @default.
• W1967138211 hasConcept C98274493 @default.
• W1967138211 hasConceptScore W1967138211C125439840 @default.
• W1967138211 hasConceptScore W1967138211C126322002 @default.
• W1967138211 hasConceptScore W1967138211C134018914 @default.
• W1967138211 hasConceptScore W1967138211C170493617 @default.
• W1967138211 hasConceptScore W1967138211C185592680 @default.
• W1967138211 hasConceptScore W1967138211C2777972943 @default.
• W1967138211 hasConceptScore W1967138211C2778555786 @default.
• W1967138211 hasConceptScore W1967138211C2778938600 @default.

• next