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- W1967156616 abstract "<h3>Objective</h3> Pancreatic cysts are commonly detected in patients undergoing pancreatic imaging. Better approaches are needed to characterise these lesions. In this study we evaluated the utility of detecting mutant DNA in secretin-stimulated pancreatic juice. <h3>Design</h3> Secretin-stimulated pancreatic juice was collected from the duodenum of 291 subjects enrolled in Cancer of the Pancreas Screening trials at five US academic medical centres. The study population included subjects with a familial predisposition to pancreatic cancer who underwent pancreatic screening, and disease controls with normal pancreata, chronic pancreatitis, sporadic intraductal papillary mucinous neoplasm (IPMN) or other neoplasms. Somatic <i>GNAS</i> mutations (reported prevalence ∼66% of IPMNs) were measured using digital high-resolution melt-curve analysis and pyrosequencing. <h3>Results</h3> <i>GNAS</i> mutations were detected in secretin-stimulated pancreatic juice samples of 50 of 78 familial and sporadic cases of IPMN(s) (64.1%), 15 of 33 (45.5%) with only diminutive cysts (<5 mm), but none of 57 disease controls. <i>GNAS</i> mutations were also detected in five of 123 screened subjects without a pancreatic cyst. Among 97 subjects who had serial pancreatic evaluations, <i>GNAS</i> mutations detected in baseline juice samples predicted subsequent emergence or increasing size of pancreatic cysts. <h3>Conclusion</h3> Duodenal collections of secretin-stimulated pancreatic juice from patients with IPMNs have a similar prevalence of mutant <i>GNAS</i> to primary IPMNs, indicating that these samples are an excellent source of mutant DNA from the pancreas. The detection of <i>GNAS</i> mutations before an IPMN is visible suggests that analysis of pancreatic juice has the potential to help in the risk stratification and surveillance of patients undergoing pancreatic screening." @default.
- W1967156616 created "2016-06-24" @default.
- W1967156616 creator A5002619402 @default.
- W1967156616 date "1958-05-01" @default.
- W1967156616 modified "2023-09-27" @default.
- W1967156616 title "Comparative Aspects of Haemolytic Disease of the Newborn" @default.
- W1967156616 doi "https://doi.org/10.1136/jcp.11.3.287-a" @default.
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